UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (UGT2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
1_MSLKW 6_ TSVFL 11_ LIQLS 16_ CYFSS 21_ GSCGK 26_ VLVWP 31_ TEYSH 36_ WINMK 41_ TILEE 46_ LVQRG 51_ HEVTV 56_ LTSSA 61_ STLVN 66_ ASKSS 71_ AIKLE 76_ VYPTS 81_ LTKNY 86_ LEDSL 91_ LKILD 96_ RWIYG 101_ VSKNT 106_ FWSYF 111_ SQLQE 116_ LCWEY 121_ YDYSN 126_ KLCKD 131_ AVLNK 136_ KLMMK 141_ LQESK 146_ FDVIL 151_ ADALN 156_ PCGEL 161_ LAELF 166_ NIPFL 171_ YSLRF 176_ SVGYT 181_ FEKNG 186_ GGFLF 191_ PPSYV 196_ PVVMS 201_ ELSDQ 206_ MIFME 211_ RIKNM 216_ IHMLY 221_ FDFWF 226_ QIYDL 231_ KKWDQ 236_ FYSEV 241_ LGRPT 246_ TLFET 251_ MGKAE 256_ MWLIR 261_ TYWDF 266_ EFPRP 271_ FLPNV 276_ DFVGG 281_ LHCKP 286_ AKPLP 291_ KEMEE 296_ FVQSS 301_ GENGI 306_ VVFSL 311_ GSMIS 316_ NMSEE 321_ SANMI 326_ ASALA 331_ QIPQK 336_ VLWRF 341_ DGKKP 346_ NTLGS 351_ NTRLY 356_ KWLPQ 361_ NDLLG 366_ HPKTK 371_ AFITH 376_ GGTNG 381_ IYEAI 386_ YHGIP 391_ MVGIP 396_ LFADQ 401_ HDNIA 406_ HMKAK 411_ GAALS 416_ VDIRT 421_ MSSRD 426_ LLNAL 431_ KSVIN 436_ DPVYK 441_ ENVMK 446_ LSRIH 451_ HDQPM 456_ KPLDR 461_ AVFWI 466_ EFVMR 471_ HKGAK 476_ HLRVA 481_ AHNLT 486_ WIQYH 491_ SLDVI 496_ AFLLA 501_ CVATV 506_ IFIIT 511_ KFCLF 516_ CFRKL 521_AKKGK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:23288867, PubMed:7835232, PubMed:9295060). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:16595710, PubMed:18719240, PubMed:23288867, PubMed:7835232, PubMed:9295060). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity)