Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
1_MQRLL 6_ TPVKR 11_ ILQLT 16_ RAVQE 21_ TSLTP 26_ ARLLP 31_ VAHQR 36_ FSTAS 41_ AVPLA 46_ KTDTW 51_ PKDVG 56_ ILALE 61_ VYFPA 66_ QYVDQ 71_ TDLEK 76_ YNNVE 81_ AGKYT 86_ VGLGQ 91_ TRMGF 96_ CSVQE 101_ DINSL 106_ CLTVV 111_ QRLME 116_ RIQLP 121_ WDSVG 126_ RLEVG 131_ TETII 136_ DKSKA 141_ VKTVL 146_ MELFQ 151_ DSGNT 156_ DIEGI 161_ DTTNA 166_ CYGGT 171_ ASLFN 176_ AANWM 181_ ESSSW 186_ DGRYA 191_ MVVCG 196_ DIAVY 201_ PSGNA 206_ RPTGG 211_ AGAVA 216_ MLIGP 221_ KAPLA 226_ LERGL 231_ RGTHM 236_ ENVYD 241_ FYKPN 246_ LASEY 251_ PIVDG 256_ KLSIQ 261_ CYLRA 266_ LDRCY 271_ TSYRK 276_ KIQNQ 281_ WKQAG 286_ SDRPF 291_ TLDDL 296_ QYMIF 301_ HTPFC 306_ KMVQK 311_ SLARL 316_ MFNDF 321_ LSASS 326_ DTQTS 331_ LYKGL 336_ EAFGG 341_ LKLED 346_ TYTNK 351_ DLDKA 356_ LLKAS 361_ QDMFD 366_ KKTKA 371_ SLYLS 376_ THNGN 381_ MYTSS 386_ LYGCL 391_ ASLLS 396_ HHSAQ 401_ ELAGS 406_ RIGAF 411_ SYGSG 416_ LAASF 421_ FSFRV 426_ SQDAA 431_ PGSPL 436_ DKLVS 441_ STSDL 446_ PKRLA 451_ SRKCV 456_ SPEEF 461_ TEIMN 466_ QREQF 471_ YHKVN 476_ FSPPG 481_ DTNSL 486_ FPGTW 491_ YLERV 496_ DEQHR 501_RKYAR
1: Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate