Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter)
1_MAELP 6_ TTETP 11_ GDATL 16_ CSGRF 21_ TISTL 26_ LSSDE 31_ PSPPA 36_ AYDSS 41_ HPSHL 46_ THSST 51_ FCMRT 56_ FGYNT 61_ IDVVP 66_ TYEHY 71_ ANSTQ 76_ PGEPR 81_ KVRPT 86_ LADLH 91_ SFLKQ 96_ EGRHL 101_ HALAF 106_ DSRPS 111_ HEMTD 116_ GLVEG 121_ EAGTS 126_ SEKNP 131_ EEPVR 136_ FGWVK 141_ GVMIR 146_ CMLNI 151_ WGVIL 156_ YLRLP 161_ WITAQ 166_ AGIVL 171_ TWIII 176_ LLSVT 181_ VTSIT 186_ GLSIS 191_ AISTN 196_ GKVKS 201_ GGTYF 206_ LISRS 211_ LGPEL 216_ GGSIG 221_ LIFAF 226_ ANAVG 231_ VAMHT 236_ VGFAE 241_ TVRDL 246_ LQEYG 251_ APIVD 256_ PINDI 261_ RIIAV 266_ VSVTV 271_ LLAIS 276_ LAGME 281_ WESKA 286_ QVLFF 291_ LVIMV 296_ SFANY 301_ LVGTL 306_ IPPSE 311_ DKASK 316_ GFFSY 321_ RADIF 326_ VQNLV 331_ PDWRG 336_ PDGTF 341_ FGMFS 346_ IFFPS 351_ ATGIL 356_ AGANI 361_ SGDLK 366_ DPAIA 371_ IPKGT 376_ LMAIF 381_ WTTIS 386_ YLAIS 391_ ATIGS 396_ CVVRD 401_ ASGVL 406_ NDTVT 411_ PGWGA 416_ CEGLA 421_ CSYGW 426_ NFTEC 431_ TQQHS 436_ CHYGL 441_ INYYQ 446_ TMSMV 451_ SGFAP 456_ LITAG 461_ IFGAT 466_ LSSAL 471_ ACLVS 476_ AAKVF 481_ QCLCE 486_ DQLYP 491_ LIGFF 496_ GKGYG 501_ KNKEP 506_ VRGYL 511_ LAYAI 516_ AVAFI 521_ IIAEL 526_ NTIAP 531_ IISNF 536_ FLCSY 541_ ALINF 546_ SCFHA 551_ SITNS 556_ PGWRP 561_ SFQYY 566_ NKWAA 571_ LFGAI 576_ ISVVI 581_ MFLLT 586_ WWAAL 591_ IAIGV 596_ VLFLL 601_ LYVIY 606_ KKPEV 611_ NWGSS 616_ VQAGS 621_ YNLAL 626_ SYSVG 631_ LNEVE 636_ DHIKN 641_ YRPQC 646_ LVLTG 651_ PPNFR 656_ PALVD 661_ FVGTF 666_ TRNLS 671_ LMICG 676_ HVLIG 681_ PHKQR 686_ MPELQ 691_ LIANG 696_ HTKWL 701_ NKRKI 706_ KAFYS 711_ DVIAE 716_ DLRRG 721_ VQILM 726_ QAAGL 731_ GRMKP 736_ NILVV 741_ GFKKN 746_ WQSAH 751_ PATVE 756_ DYIGI 761_ LHDAF 766_ DFNYG 771_ VCVMR 776_ MREGL 781_ NVSKM 786_ MQAHI 791_ NPVFD 796_ PAEDG 801_ KEASA 806_ RVDPK 811_ ALVKE 816_ EQATT 821_ IFQSE 826_ QGKKT 831_ IDIYW 836_ LFDDG 841_ GLTLL 846_ IPYLL 851_ GRKRR 856_ WSKCK 861_ IRVFV 866_ GGQIN 871_ RMDQE 876_ RKAII 881_ SLLSK 886_ FRLGF 891_ HEVHI 896_ LPDIN 901_ QNPRA 906_ EHTKR 911_ FEDMI 916_ APFRL 921_ NDGFK 926_ DEATV 931_ NEMRR 936_ DCPWK 941_ ISDEE 946_ ITKNR 951_ VKSLR 956_ QVRLN 961_ EIVLD 966_ YSRDA 971_ ALIVI 976_ TLPIG 981_ RKGKC 986_ PSSLY 991_ MAWLE 996_ TLSQD 1001_ LRPPV 1006_ ILIRG 1011_ NQENV 1016_LTFYC
1: Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145, PubMed:36351028, PubMed:36792826). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity)