26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
1_MVLES 6_ TMVCV 11_ DNSEY 16_ MRNGD 21_ FLPTR 26_ LQAQQ 31_ DAVNI 36_ VCHSK 41_ TRSNP 46_ ENNVG 51_ LITLA 56_ NDCEV 61_ LTTLT 66_ PDTGR 71_ ILSKL 76_ HTVQP 81_ KGKIT 86_ FCTGI 91_ RVAHL 96_ ALKHR 101_ QGKNH 106_ KMRII 111_ AFVGS 116_ PVEDN 121_ EKDLV 126_ KLAKR 131_ LKKEK 136_ VNVDI 141_ INFGE 146_ EEVNT 151_ EKLTA 156_ FVNTL 161_ NGKDG 166_ TGSHL 171_ VTVPP 176_ GPSLA 181_ DALIS 186_ SPILA 191_ GEGGA 196_ MLGLG 201_ ASDFE 206_ FGVDP 211_ SADPE 216_ LALAL 221_ RVSME 226_ EQRQR 231_ QEEEA 236_ RRAAA 241_ ASAAE 246_ AGIAT 251_ TGTED 256_ SDDAL 261_ LKMTI 266_ SQQEF 271_ GRTGL 276_ PDLSS 281_ MTEEE 286_ QIAYA 291_ MQMSL 296_ QGAEF 301_ GQAES 306_ ADIDA 311_ SSAMD 316_ TSEPA 321_ KEEDD 326_ YDVMQ 331_ DPEFL 336_ QSVLE 341_ NLPGV 346_ DPNNE 351_ AIRNA 356_ MGSLA 361_ SQATK 366_ DGKKD 371_KKEED
1: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains