Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)
1_MSSPT 6_ TSSLD 11_ TPLPG 16_ NGPPQ 21_ PGAPS 26_ SSPTV 31_ KEEGP 36_ EPWPG 41_ GPDPD 46_ VPGTD 51_ EASSA 56_ CSTDW 61_ VIPDP 66_ EEEPE 71_ RKRKK 76_ GPAPK 81_ MLGHE 86_ LCRVC 91_ GDKAS 96_ GFHYN 101_ VLSCE 106_ GCKGF 111_ FRRSV 116_ VRGGA 121_ RRYAC 126_ RGGGT 131_ CQMDA 136_ FMRRK 141_ CQQCR 146_ LRKCK 151_ EAGMR 156_ EQCVL 161_ SEEQI 166_ RKKKI 171_ RKQQQ 176_ ESQSQ 181_ SQSPV 186_ GPQGS 191_ SSSAS 196_ GPGAS 201_ PGGSE 206_ AGSQG 211_ SGEGE 216_ GVQLT 221_ AAQEL 226_ MIQQL 231_ VAAQL 236_ QCNKR 241_ SFSDQ 246_ PKVTP 251_ WPLGA 256_ DPQSR 261_ DARQQ 266_ RFAHF 271_ TELAI 276_ ISVQE 281_ IVDFA 286_ KQVPG 291_ FLQLG 296_ REDQI 301_ ALLKA 306_ STIEI 311_ MLLET 316_ ARRYN 321_ HETEC 326_ ITFLK 331_ DFTYS 336_ KDDFH 341_ RAGLQ 346_ VEFIN 351_ PIFEF 356_ SRAMR 361_ RLGLD 366_ DAEYA 371_ LLIAI 376_ NIFSA 381_ DRPNV 386_ QEPGR 391_ VEALQ 396_ QPYVE 401_ ALLSY 406_ TRIKR 411_ PQDQL 416_ RFPRM 421_ LMKLV 426_ SLRTL 431_ SSVHS 436_ EQVFA 441_ LRLQD 446_ KKLPP 451_LLSEI
1: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957)