Phospholipid transfer protein (Lipid transfer protein II)
1_MALFG 6_ ALFLA 11_ LLAGA 16_ HAEFP 21_ GCKIR 26_ VTSKA 31_ LELVK 36_ QEGLR 41_ FLEQE 46_ LETIT 51_ IPDLR 56_ GKEGH 61_ FYYNI 66_ SEVKV 71_ TELQL 76_ TSSEL 81_ DFQPQ 86_ QELML 91_ QITNA 96_ SLGLR 101_ FRRQL 106_ LYWFF 111_ YDGGY 116_ INASA 121_ EGVSI 126_ RTGLE 131_ LSRDP 136_ AGRMK 141_ VSNVS 146_ CQASV 151_ SRMHA 156_ AFGGT 161_ FKKVY 166_ DFLST 171_ FITSG 176_ MRFLL 181_ NQQIC 186_ PVLYH 191_ AGTVL 196_ LNSLL 201_ DTVPV 206_ RSSVD 211_ ELVGI 216_ DYSLM 221_ KDPVA 226_ STSNL 231_ DMDFR 236_ GAFFP 241_ LTERN 246_ WSLPN 251_ RAVEP 256_ QLQEE 261_ ERMVY 266_ VAFSE 271_ FFFDS 276_ AMESY 281_ FRAGA 286_ LQLLL 291_ VGDKV 296_ PHDLD 301_ MLLRA 306_ TYFGS 311_ IVLLS 316_ PAVID 321_ SPLKL 326_ ELRVL 331_ APPRC 336_ TIKPS 341_ GTTIS 346_ VTASV 351_ TIALV 356_ PPDQP 361_ EVQLS 366_ SMTMD 371_ ARLSA 376_ KMALR 381_ GKALR 386_ TQLDL 391_ RRFRI 396_ YSNHS 401_ ALESL 406_ ALIPL 411_ QAPLK 416_ TMLQI 421_ GVMPM 426_ LNERT 431_ WRGVQ 436_ IPLPE 441_ GINFV 446_ HEVVT 451_ NHAGF 456_ LTIGA 461_ DLHFA 466_ KGLRE 471_ VIEKN 476_ RPADV 481_ RASTA 486_PTPST
1: Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves (PubMed:11013307, PubMed:19321130, PubMed:21515415, PubMed:29883800, PubMed:7654777, PubMed:9132017). Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine (PubMed:9132017). Plays an important role in HDL remodeling which involves modulating the size and composition of HDL (PubMed:29883800). Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion (PubMed:21736953). Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability (PubMed:11013307)