Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)
1_MELSD 6_ ANLQT 11_ LTEYL 16_ KKTLD 21_ PDPAI 26_ RRPAE 31_ KFLES 36_ VEGNQ 41_ NYPLL 46_ LLTLL 51_ EKSQD 56_ NVIKV 61_ CASVT 66_ FKNYI 71_ KRNWR 76_ IVEDE 81_ PNKIC 86_ EADRV 91_ AIKAN 96_ IVHLM 101_ LSSPE 106_ QIQKQ 111_ LSDAI 116_ SIIGR 121_ EDFPQ 126_ KWPDL 131_ LTEMV 136_ NRFQS 141_ GDFHV 146_ INGVL 151_ RTAHS 156_ LFKRY 161_ RHEFK 166_ SNELW 171_ TEIKL 176_ VLDAF 181_ ALPLT 186_ NLFKA 191_ TIELC 196_ STHAN 201_ DASAL 206_ RILFS 211_ SLILI 216_ SKLFY 221_ SLNFQ 226_ DLPEF 231_ FEDNM 236_ ETWMN 241_ NFHTL 246_ LTLDN 251_ KLLQT 256_ DDEEE 261_ AGLLE 266_ LLKSQ 271_ ICDNA 276_ ALYAQ 281_ KYDEE 286_ FQRYL 291_ PRFVT 296_ AIWNL 301_ LVTTG 306_ QEVKY 311_ DLLVS 316_ NAIQF 321_ LASVC 326_ ERPHY 331_ KNLFE 336_ DQNTL 341_ TSICE 346_ KVIVP 351_ NMEFR 356_ AADEE 361_ AFEDN 366_ SEEYI 371_ RRDLE 376_ GSDID 381_ TRRRA 386_ ACDLV 391_ RGLCK 396_ FFEGP 401_ VTGIF 406_ SGYVN 411_ SMLQE 416_ YAKNP 421_ SVNWK 426_ HKDAA 431_ IYLVT 436_ SLASK 441_ AQTQK 446_ HGITQ 451_ ANELV 456_ NLTEF 461_ FVNHI 466_ LPDLK 471_ SANVN 476_ EFPVL 481_ KADGI 486_ KYIMI 491_ FRNQV 496_ PKEHL 501_ LVSIP 506_ LLINH 511_ LQAES 516_ IVVHT 521_ YAAHA 526_ LERLF 531_ TMRGP 536_ NNATL 541_ FTAAE 546_ IAPFV 551_ EILLT 556_ NLFKA 561_ LTLPG 566_ SSENE 571_ YIMKA 576_ IMRSF 581_ SLLQE 586_ AIIPY 591_ IPTLI 596_ TQLTQ 601_ KLLAV 606_ SKNPS 611_ KPHFN 616_ HYMFE 621_ AICLS 626_ IRITC 631_ KANPA 636_ AVVNF 641_ EEALF 646_ LVFTE 651_ ILQND 656_ VQEFI 661_ PYVFQ 666_ VMSLL 671_ LETHK 676_ NDIPS 681_ SYMAL 686_ FPHLL 691_ QPVLW 696_ ERTGN 701_ IPALV 706_ RLLQA 711_ FLERG 716_ SNTIA 721_ SAAAD 726_ KIPGL 731_ LGVFQ 736_ KLIAS 741_ KANDH 746_ QGFYL 751_ LNSII 756_ EHMPP 761_ ESVDQ 766_ YRKQI 771_ FILLF 776_ QRLQN 781_ SKTTK 786_ FIKSF 791_ LVFIN 796_ LYCIK 801_ YGALA 806_ LQEIF 811_ DGIQP 816_ KMFGM 821_ VLEKI 826_ IIPEI 831_ QKVSG 836_ NVEKK 841_ ICAVG 846_ ITKLL 851_ TECPP 856_ MMDTE 861_ YTKLW 866_ TPLLQ 871_ SLIGL 876_ FELPE 881_ DDTIP 886_ DEEHF 891_ IDIED 896_ TPGYQ 901_ TAFSQ 906_ LAFAG 911_ KKEHD 916_ PVGQM 921_ VNNPK 926_ IHLAQ 931_ SLHKL 936_ STACP 941_ GRVPS 946_ MVSTS 951_ LNAEA 956_ LQYLQ 961_ GYLQA 966_ASVTL
1: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus