Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6)
1_MNIFD 6_ RKINF 11_ DALLK 16_ FSHIT 21_ PSTQQ 26_ HLKKV 31_ YASFA 36_ LCMFV 41_ AAAGA 46_ YVHMV 51_ THFIQ 56_ AGLLS 61_ ALGSL 66_ ILMIW 71_ LMATP 76_ HSHET 81_ EQKRL 86_ GLLAG 91_ FAFLT 96_ GVGLG 101_ PALEF 106_ CIAVN 111_ PSILP 116_ TAFMG 121_ TAMIF 126_ TCFTL 131_ SALYA 136_ RRRSY 141_ LFLGG 146_ ILMSA 151_ LSLLL 156_ LSSLG 161_ NVFFG 166_ SIWLF 171_ QANLY 176_ VGLVV 181_ MCGFV 186_ LFDTQ 191_ LIIEK 196_ AEHGD 201_ QDYIW 206_ HCIDL 211_ FLDFI 216_ TVFRK 221_ LMMIL 226_ AMNEK 231_DKKKE
1: Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria (PubMed:21075086, PubMed:21068390). Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding (PubMed:19328063). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity)