Aquaporin-5 (AQP-5)
1_MKKEV 6_ CSVAF 11_ LKAVF 16_ AEFLA 21_ TLIFV 26_ FFGLG 31_ SALKW 36_ PSALP 41_ TILQI 46_ ALAFG 51_ LAIGT 56_ LAQAL 61_ GPVSG 66_ GHINP 71_ AITLA 76_ LLVGN 81_ QISLL 86_ RAFFY 91_ VAAQL 96_ VGAIA 101_ GAGIL 106_ YGVAP 111_ LNARG 116_ NLAVN 121_ ALNNN 126_ TTQGQ 131_ AMVVE 136_ LILTF 141_ QLALC 146_ IFAST 151_ DSRRT 156_ SPVGS 161_ PALSI 166_ GLSVT 171_ LGHLV 176_ GIYFT 181_ GCSMN 186_ PARSF 191_ GPAVV 196_ MNRFS 201_ PAHWV 206_ FWVGP 211_ IVGAV 216_ LAAIL 221_ YFYLL 226_ FPNSL 231_ SLSER 236_ VAIIK 241_ GTYEP 246_ DEDWE 251_ EQREE 256_RKKTM
1: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:18768791, PubMed:8621489). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity)