Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
1_MASGA 6_ DSKGD 11_ DLSTA 16_ ILKQK 21_ NRPNR 26_ LIVDE 31_ AINED 36_ NSVVS 41_ LSQPK 46_ MDELQ 51_ LFRGD 56_ TVLLK 61_ GKKRR 66_ EAVCI 71_ VLSDD 76_ TCSDE 81_ KIRMN 86_ RVVRN 91_ NLRVR 96_ LGDVI 101_ SIQPC 106_ PDVKY 111_ GKRIH 116_ VLPID 121_ DTVEG 126_ ITGNL 131_ FEVYL 136_ KPYFL 141_ EAYRP 146_ IRKGD 151_ IFLVR 156_ GGMRA 161_ VEFKV 166_ VETDP 171_ SPYCI 176_ VAPDT 181_ VIHCE 186_ GEPIK 191_ REDEE 196_ ESLNE 201_ VGYDD 206_ IGGCR 211_ KQLAQ 216_ IKEMV 221_ ELPLR 226_ HPALF 231_ KAIGV 236_ KPPRG 241_ ILLYG 246_ PPGTG 251_ KTLIA 256_ RAVAN 261_ ETGAF 266_ FFLIN 271_ GPEIM 276_ SKLAG 281_ ESESN 286_ LRKAF 291_ EEAEK 296_ NAPAI 301_ IFIDE 306_ LDAIA 311_ PKREK 316_ THGEV 321_ ERRIV 326_ SQLLT 331_ LMDGL 336_ KQRAH 341_ VIVMA 346_ ATNRP 351_ NSIDP 356_ ALRRF 361_ GRFDR 366_ EVDIG 371_ IPDAT 376_ GRLEI 381_ LQIHT 386_ KNMKL 391_ ADDVD 396_ LEQVA 401_ NETHG 406_ HVGAD 411_ LAALC 416_ SEAAL 421_ QAIRK 426_ KMDLI 431_ DLEDE 436_ TIDAE 441_ VMNSL 446_ AVTMD 451_ DFRWA 456_ LSQSN 461_ PSALR 466_ ETVVE 471_ VPQVT 476_ WEDIG 481_ GLEDV 486_ KRELQ 491_ ELVQY 496_ PVEHP 501_ DKFLK 506_ FGMTP 511_ SKGVL 516_ FYGPP 521_ GCGKT 526_ LLAKA 531_ IANEC 536_ QANFI 541_ SIKGP 546_ ELLTM 551_ WFGES 556_ EANVR 561_ EIFDK 566_ ARQAA 571_ PCVLF 576_ FDELD 581_ SIAKA 586_ RGGNI 591_ GDGGG 596_ AADRV 601_ INQIL 606_ TEMDG 611_ MSTKK 616_ NVFII 621_ GATNR 626_ PDIID 631_ PAILR 636_ PGRLD 641_ QLIYI 646_ PLPDE 651_ KSRVA 656_ ILKAN 661_ LRKSP 666_ VAKDV 671_ DLEFL 676_ AKMTN 681_ GFSGA 686_ DLTEI 691_ CQRAC 696_ KLAIR 701_ ESIES 706_ EIRRE 711_ RERQT 716_ NPSAM 721_ EVEED 726_ DPVPE 731_ IRRDH 736_ FEEAM 741_ RFARR 746_ SVSDN 751_ DIRKY 756_ EMFAQ 761_ TLQQS 766_ RGFGS 771_ FRFPS 776_ GNQGG 781_ AGPSQ 786_ GSGGG 791_ TGGSV 796_ YTEDN 801_DDDLY
1: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Mediates the endoplasmic reticulum-associated degradation of CHRNA3 in cortical neurons as part of the STUB1-VCP-UBXN2A complex (PubMed:26265139). Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Involved in clearance process by mediating G3BP1 extraction from stress granules (PubMed:29804830, PubMed:34739333). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042605, PubMed:23042607). Together with SPRTN metalloprotease, involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis (PubMed:32152270). Involved in interstrand cross-link repair in response to replication stress by mediating unloading of the ubiquitinated CMG helicase complex (By similarity). Mediates extraction of PARP1 trapped to chromatin: recognizes and binds ubiquitinated PARP1 and promotes its removal (PubMed:35013556). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022, PubMed:27753622). Acts as a negative regulator of type I interferon production by interacting with RIGI: interaction takes place when RIGI is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of RIGI (PubMed:26471729). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (PubMed:21822278). May more particularly play a role in caveolins sorting in cells (PubMed:21822278, PubMed:23335559). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333)