Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase)
1_MPRQA 6_ TSRLV 11_ VGEGE 16_ GSQGA 21_ SGPAA 26_ TMLRS 31_ LLLHS 36_ LRLCA 41_ QTASC 46_ LVLFP 51_ RFLGT 56_ AFMLW 61_ LLDFL 66_ CIRKH 71_ FLGRR 76_ RRGQP 81_ EPEVE 86_ LNSEG 91_ EEVPP 96_ DDPPI 101_ CVSDD 106_ NRLCT 111_ LASLK 116_ AVWHG 121_ QKLDF 126_ FKQAH 131_ EGGPA 136_ PNSEV 141_ VLPDG 146_ FQSQH 151_ ILDYA 156_ QGNRP 161_ LVLNF 166_ GSCTU 171_ PPFMA 176_ RMSAF 181_ QRLVT 186_ KYQRD 191_ VDFLI 196_ IYIEE 201_ AHPSD 206_ GWVTT 211_ DSPYI 216_ IPQHR 221_ SLEDR 226_ VSAAR 231_ VLQQG 236_ APGCA 241_ LVLDT 246_ MANSS 251_ SSAYG 256_ AYFER 261_ LYVIQ 266_ SGTIM 271_ YQGGR 276_ GPDGY 281_ QVSEL 286_ RTWLE 291_ RYDEQ 296_LHGAR
1: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722, PubMed:18339710). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (PubMed:18821722). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine (PubMed:18339710)