Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]
1_MTILT 6_ YPFKN 11_ LPTAS 16_ KWALR 21_ FSIRP 26_ LSCSS 31_ QLRAA 36_ PAVQT 41_ KTKKT 46_ LAKPN 51_ IRNVV 56_ VVDGV 61_ RTPFL 66_ LSGTS 71_ YKDLM 76_ PHDLA 81_ RAALT 86_ GLLHR 91_ TSVPK 96_ EVVDY 101_ IIFGT 106_ VIQEV 111_ KTSNV 116_ AREAA 121_ LGAGF 126_ SDKTP 131_ AHTVT 136_ MACIS 141_ ANQAM 146_ TTGVG 151_ LIASG 156_ QCDVI 161_ VAGGV 166_ ELMSD 171_ VPIRH 176_ SRKMR 181_ KLMLD 186_ LNKAK 191_ SMGQR 196_ LSLIS 201_ KFRFN 206_ FLAPE 211_ LPAVS 216_ EFSTS 221_ ETMGH 226_ SADRL 231_ AAAFA 236_ VSRLE 241_ QDEYA 246_ LRSHS 251_ LAKKA 256_ QDEGL 261_ LSDVV 266_ PFKVP 271_ GKDTV 276_ TKDNG 281_ IRPSS 286_ LEQMA 291_ KLKPA 296_ FIKPY 301_ GTVTA 306_ ANSSF 311_ LTDGA 316_ SAMLI 321_ MAEEK 326_ ALAMG 331_ YKPKA 336_ YLRDF 341_ MYVSQ 346_ DPKDQ 351_ LLLGP 356_ TYATP 361_ KVLEK 366_ AGLTM 371_ NDIDA 376_ FEFHE 381_ AFSGQ 386_ ILANF 391_ KAMDS 396_ DWFAE 401_ NYMGR 406_ KTKVG 411_ LPPLE 416_ KFNNW 421_ GGSLS 426_ LGHPF 431_ GATGC 436_ RLVMA 441_ AANRL 446_ RKEGG 451_ QYGLV 456_ AACAA 461_ GGQGH 466_AMIVE
1: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:29915090, PubMed:30850536, PubMed:8135828). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:29915090, PubMed:30850536, PubMed:8135828)