Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
1_MSDRP 6_ TARRW 11_ GKCGP 16_ LCTRE 21_ NIMVA 26_ FKGVW 31_ TQAFW 36_ KAVTA 41_ EFLAM 46_ LIFVL 51_ LSLGS 56_ TINWG 61_ GTEKP 66_ LPVDM 71_ VLISL 76_ CFGLS 81_ IATMV 86_ QCFGH 91_ ISGGH 96_ INPAV 101_ TVAMV 106_ CTRKI 111_ SIAKS 116_ VFYIA 121_ AQCLG 126_ AIIGA 131_ GILYL 136_ VTPPS 141_ VVGGL 146_ GVTMV 151_ HGNLT 156_ AGHGL 161_ LVELI 166_ ITFQL 171_ VFTIF 176_ ASCDS 181_ KRTDV 186_ TGSIA 191_ LAIGF 196_ SVAIG 201_ HLFAI 206_ NYTGA 211_ SMNPA 216_ RSFGP 221_ AVIMG 226_ NWENH 231_ WIYWV 236_ GPIIG 241_ AVLAG 246_ GLYEY 251_ VFCPD 256_ VEFKR 261_ RFKEA 266_ FSKAA 271_ QQTKG 276_ SYMEV 281_ EDNRS 286_ QVETD 291_ DLILK 296_ PGVVH 301_ VIDVD 306_ RGEEK 311_ KGKDQ 316_SGEVL
1: Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity)