Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET)
1_MRRMW 6_ ATQGL 11_ AVALA 16_ LSVLP 21_ GSRAL 26_ RPGDC 31_ EVCIS 36_ YLGRF 41_ YQDLK 46_ DRDVT 51_ FSPAT 56_ IENEL 61_ IKFCR 66_ EARGK 71_ ENRLC 76_ YYIGA 81_ TDDAA 86_ TKIIN 91_ EVSKP 96_ LAHHI 101_ PVEKI 106_ CEKLK 111_ KKDSQ 116_ ICELK 121_ YDKQI 126_ DLSTV 131_ DLKKL 136_ RVKEL 141_ KKILD 146_ DWGET 151_ CKGCA 156_ EKSDY 161_ IRKIN 166_ ELMPK 171_ YAPKA 176_ASART
1: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PubMed:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra (By similarity). Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PubMed:18561914, PubMed:22637475, PubMed:29497057, PubMed:36739529). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PubMed:22637475). Stabilizes HSPA5/BiP in its substrate-bound ADP state, which facilitates HSPA5/BiP incorporation into chaperone-client complexes during endoplasmic reticulum stress, its interaction with HSPA5/BiP inhibits ATP binding to HSPA5/BiP and subsequent nucleotide exchange (By similarity). As a result acts as a repressor of the unfolded protein response (UPR) pathway (By similarity). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PubMed:29497057). Essential for embryonic lung development (By similarity). Required for the correct postnatal temporal and structural development of splenic white pulp (By similarity). Required for the repair-associated myeloid response in skeletal muscle, acts as a regulator of phenotypic transition towards prorepair macrophages in response to muscle injury and as a result limits excessive proinflammatory signaling (By similarity). Represses RELA expression and therefore NF-kB signaling in the myocardium, as a result limits macrophage infiltration of injured tissue and M1 macrophage differentiation in response to myocardial injury (By similarity). Required for endochondral ossification in long bones and the skull during postnatal development (By similarity)