Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1)
1_MSLTS 6_ AYQHK 11_ LAEKL 16_ TILND 21_ RGQGV 26_ LIRMY 31_ NIKKT 36_ CSDPK 41_ SKPPF 46_ LLEKS 51_ MEPSL 56_ KYINK 61_ KFPNI 66_ DVRNS 71_ TQHLG 76_ PVHRE 81_ KAEII 86_ RFLTN 91_ YYQSF 96_ VDVME 101_ FRDHV 106_ YELLN 111_ TIDAC 116_ QCHFD 121_ INLNF 126_ DFTRS 131_ YLDLI 136_ VTYTS 141_ VILLL 146_ SRIED 151_ RRILI 156_ GMYNC 161_ AHEML 166_ HGHGD 171_ PSFAR 176_ LGQMV 181_ LEYDH 186_ PLKKL 191_ TEEFG 196_ PHTKA 201_ VSGAL 206_ LSLHF 211_ LFVRR 216_ NQGAE 221_ QWRSA 226_ QLLSL 231_ ISNPP 236_ AMINP 241_ ANSDT 246_ MACEY 251_ LSVEV 256_ MERWI 261_ IIGFL 266_ LCHGC 271_ LNSNS 276_ QCQKL 281_ WKLCL 286_ QGSLY 291_ ITLIR 296_ EDVLQ 301_ VHKVT 306_ EDLFS 311_ SLKGY 316_ GKRVA 321_ DIKES 326_ KEHVI 331_ ANSGQ 336_ FHCQR 341_ RQFLR 346_ MAVKE 351_ LETVL 356_ ADEPG 361_ LLGPK 366_ ALFAF 371_ MALSF 376_ IRDEV 381_ TWLVR 386_ HTENV 391_ TKTKT 396_ PEDYA 401_ DSSIA 406_ ELLFL 411_ LEGIR 416_ SLVRR 421_ HIKVI 426_ QQYHL 431_ QYLAR 436_ FDALV 441_ LSDII 446_ QNLSV 451_ CPEEE 456_ SIIMS 461_ SFVSI 466_ LSSLN 471_ LKQVD 476_ NGEKF 481_ EFSGL 486_ RLDWF 491_ RLQAY 496_ TSVAK 501_ APLHL 506_ HENPD 511_ LAKVM 516_ NLIVF 521_ HSRML 526_ DSVEK 531_ LLVET 536_ SDLST 541_ FCFHL 546_ RIFEK 551_ MFAMT 556_ LEESA 561_ MLRYA 566_ IAFPL 571_ ICAHF 576_ VHCTH 581_ EMCPE 586_ EYPHL 591_ KNHGL 596_ HHCNS 601_ FLEEL 606_ AKQTS 611_ NCVLE 616_ ICAEQ 621_ RNLSE 626_ QLLPK 631_ HCATT 636_ ISKAK 641_ NKKTR 646_ KQRQT 651_ PRKGE 656_ PERDK 661_ PGAES 666_ HRKNR 671_ SIVTN 676_ MDKLH 681_ LNLTE 686_ LALTM 691_ NHVYS 696_ FSVFE 701_ HTIFP 706_ SEYLS 711_ SHLEA 716_ RLNRA 721_ IVWLA 726_ GYNAT 731_ TQEIV 736_ RPSEL 741_ LAGVK 746_ AYIGF 751_ IQSLA 756_ QFLGA 761_ DASRV 766_ IRNAL 771_ LQQTQ 776_ PLDSC 781_ GEQTI 786_ TTLYT 791_ NWYLE 796_ SLLRQ 801_ ASSGT 806_ IILSP 811_ AMQAF 816_ VSLPR 821_ EGEQN 826_ FSAEE 831_ FSDIS 836_ EMRAL 841_ AELLG 846_ PYGMK 851_ FLSEN 856_ LMWHV 861_ TSQIV 866_ ELKKL 871_ VVENM 876_ DILVQ 881_ IRSNF 886_ SKPDL 891_ MASLL 896_ PQLTG 901_ AENVL 906_ KRMTI 911_ IGVIL 916_ SFRAM 921_ AQEGL 926_ REVFS 931_ SHCPF 936_ LMGPI 941_ ECLKE 946_ FVTPD 951_ TDIKV 956_ TLSIF 961_ ELASA 966_ AGVGC 971_ DIDPA 976_ LVAAI 981_ ANLKA 986_ DTSSP 991_ EEEYK 996_ VACLL 1001_ LIFLA 1006_ VSLPL 1011_ LATDP 1016_ SSFYS 1021_ IEKDG 1026_ YNNNI 1031_ HCLTK 1036_ AIIQV 1041_ SAALF 1046_ TLYNK 1051_ NIETH 1056_ LKEFL 1061_ VVASV 1066_ SLLQL 1071_ GQETD 1076_ KLKTR 1081_ NRESI 1086_ SLLMR 1091_ LVVEE 1096_ SSFLT 1101_ LDMLE 1106_ SCFPY 1111_ VLLRN 1116_ AYREV 1121_SRAFH
1: Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:16417406, PubMed:17696648). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells (PubMed:32647003). Required for efficient T-lymphocyte and neutrophil migration (PubMed:32647003). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin (PubMed:16417406). Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis (PubMed:17696648). In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (PubMed:32647003)