Protein AF-10 (ALL1-fused gene from chromosome 10 protein)
1_MVSSD 6_ RPVSL 11_ EDEVS 16_ HSMKE 21_ MIGGC 26_ CVCSD 31_ ERGWA 36_ ENPLV 41_ YCDGH 46_ GCSVA 51_ VHQAC 56_ YGIVQ 61_ VPTGP 66_ WFCRK 71_ CESQE 76_ RAARV 81_ RCELC 86_ PHKDG 91_ ALKRT 96_ DNGGW 101_ AHVVC 106_ ALYIP 111_ EVQFA 116_ NVSTM 121_ EPIVL 126_ QSVPH 131_ DRYNK 136_ TCYIC 141_ DEQGR 146_ ESKAA 151_ TGACM 156_ TCNKH 161_ GCRQA 166_ FHVTC 171_ AQFAG 176_ LLCEE 181_ EGNGA 186_ DNVQY 191_ CGYCK 196_ YHFSK 201_ LKKSK 206_ RGSNR 211_ SYDQS 216_ LSDSS 221_ SHSQD 226_ KHHEK 231_ EKKKY 236_ KEKDK 241_ HKQKH 246_ KKQPE 251_ PSPAL 256_ VPSLT 261_ VTTEK 266_ TYTST 271_ SNNSI 276_ SGSLK 281_ RLEDT 286_ TARFT 291_ NANFQ 296_ EVSAH 301_ TSSGK 306_ DVSET 311_ RGSEG 316_ KGKKS 321_ SAHSS 326_ GQRGR 331_ KPGGG 336_ RNPGT 341_ TVSAA 346_ SPFPQ 351_ GSFSG 356_ TPGSV 361_ KSSSG 366_ SSVQS 371_ PQDFL 376_ SFTDS 381_ DLRND 386_ SYSHS 391_ QQSSA 396_ TKDVH 401_ KGESG 406_ SQEGG 411_ VNSFS 416_ TLIGL 421_ PSTSA 426_ VTSQP 431_ KSFEN 436_ SPGDL 441_ GNSSL 446_ PTAGY 451_ KRAQT 456_ SGIEE 461_ ETVKE 466_ KKRKG 471_ NKQSK 476_ HGPGR 481_ PKGNK 486_ NQENV 491_ SHLSV 496_ SSASP 501_ TSSVA 506_ SAAGS 511_ ITSSS 516_ LQKSP 521_ TLLRN 526_ GSLQS 531_ LSVGS 536_ SPVGS 541_ EISMQ 546_ YRHDG 551_ ACPTT 556_ TFSEL 561_ LNAIH 566_ NGIYN 571_ SNDVA 576_ VSFPN 581_ VVSGS 586_ GSSTP 591_ VSSSH 596_ LPQQS 601_ SGHLQ 606_ QVGAL 611_ SPSAV 616_ SSAAP 621_ AVATT 626_ QANTL 631_ SGSSL 636_ SQAPS 641_ HMYGN 646_ RSNSS 651_ MAALI 656_ AQSEN 661_ NQTDQ 666_ DLGDN 671_ SRNLV 676_ GRGSS 681_ PRGSL 686_ SPRSP 691_ VSSLQ 696_ IRYDQ 701_ PGNSS 706_ LENLP 711_ PVAAS 716_ IEQLL 721_ ERQWS 726_ EGQQF 731_ LLEQG 736_ TPSDI 741_ LGMLK 746_ SLHQL 751_ QVENR 756_ RLEEQ 761_ IKNLT 766_ AKKER 771_ LQLLN 776_ AQLSV 781_ PFPTI 786_ TANPS 791_ PSHQI 796_ HTFSA 801_ QTAPT 806_ TDSLN 811_ SSKSP 816_ HIGNS 821_ FLPDN 826_ SLPVL 831_ NQDLT 836_ SSGQS 841_ TSSSS 846_ ALSTP 851_ PPAGQ 856_ SPAQQ 861_ GSGVS 866_ GVQQV 871_ NGVTV 876_ GALAS 881_ GMQPV 886_ TSTIP 891_ AVSAV 896_ GGIIG 901_ ALPGN 906_ QLAIN 911_ GIVGA 916_ LNGVM 921_ QTPVT 926_ MSQNP 931_ TPLTH 936_ TTVPP 941_ NATHP 946_ MPATL 951_ TNSAS 956_ GLGLL 961_ SDQQR 966_ QILIH 971_ QQQFQ 976_ QLLNS 981_ QQLTP 986_ EQHQA 991_ FLYQL 996_ MQHHH 1001_ QQHHQ 1006_ PELQQ 1011_ LQIPG 1016_ PTQIP 1021_ INNLL 1026_ AGTQA 1031_ PPLHT 1036_ ATTNP 1041_ FLTIH 1046_ GDNAS 1051_ QKVAR 1056_ LSDKT 1061_GPVAQ
1: Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302)