Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)
1_MADID 6_ NKEQS 11_ ELDQD 16_ LDDVE 21_ EVEEE 26_ ETGEE 31_ TKLKA 36_ RQLTV 41_ QMMQN 46_ PQILA 51_ ALQER 56_ LDGLV 61_ ETPTG 66_ YIESL 71_ PRVVK 76_ RRVNA 81_ LKNLQ 86_ VKCAQ 91_ IEAKF 96_ YEEVH 101_ DLERK 106_ YAVLY 111_ QPLFD 116_ KRFEI 121_ INAIY 126_ EPTEE 131_ ECEWK 136_ PDEED 141_ EISEE 146_ LKEKA 151_ KIEDE 156_ KKDEE 161_ KEDPK 166_ GIPEF 171_ WLTVF 176_ KNVDL 181_ LSDMV 186_ QEHDE 191_ PILKH 196_ LKDIK 201_ VKFSD 206_ AGQPM 211_ SFVLE 216_ FHFEP 221_ NEYFT 226_ NEVLT 231_ KTYRM 236_ RSEPD 241_ DSDPF 246_ SFDGP 251_ EIMGC 256_ TGCQI 261_ DWKKG 266_ KNVTL 271_ KTIKK 276_ KQKHK 281_ GRGTV 286_ RTVTK 291_ TVSND 296_ SFFNF 301_ FAPPE 306_ VPESG 311_ DLDDD 316_ AEAIL 321_ AADFE 326_ IGHFL 331_ RERII 336_ PRSVL 341_ YFTGE 346_ AIEDD 351_ DDDYD 356_ EEGEE 361_ ADEEG 366_ EEEGD 371_ EENDP 376_ DYDPK 381_ KDQNP 386_AECKQ
1: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity)
2: (Microbial infection) Positively regulates Epstein-Barr virus reactivation in epithelial cells through the induction of viral BZLF1 expression
3: (Microbial infection) Together with human herpesvirus 8 protein LANA1, assists the proper assembly of the nucleosome on the replicated viral DNA