Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
1_MDEAD 6_ RRLLR 11_ RCRLR 16_ LVEEL 21_ QVDQL 26_ WDALL 31_ SRELF 36_ RPHMI 41_ EDIQR 46_ AGSGS 51_ RRDQA 56_ RQLII 61_ DLETR 66_ GSQAL 71_ PLFIS 76_ CLEDT 81_ GQDML 86_ ASFLR 91_ TNRQA 96_ AKLSK 101_ PTLEN 106_ LTPVV 111_ LRPEI 116_ RKPEV 121_ LRPET 126_ PRPVD 131_ IGSGG 136_ FGDVG 141_ ALESL 146_ RGNAD 151_ LAYIL 156_ SMEPC 161_ GHCLI 166_ INNVN 171_ FCRES 176_ GLRTR 181_ TGSNI 186_ DCEKL 191_ RRRFS 196_ SLHFM 201_ VEVKG 206_ DLTAK 211_ KMVLA 216_ LLELA 221_ QQDHG 226_ ALDCC 231_ VVVIL 236_ SHGCQ 241_ ASHLQ 246_ FPGAV 251_ YGTDG 256_ CPVSV 261_ EKIVN 266_ IFNGT 271_ SCPSL 276_ GGKPK 281_ LFFIQ 286_ ACGGE 291_ QKDHG 296_ FEVAS 301_ TSPED 306_ ESPGS 311_ NPEPD 316_ ATPFQ 321_ EGLRT 326_ FDQLD 331_ AISSL 336_ PTPSD 341_ IFVSY 346_ STFPG 351_ FVSWR 356_ DPKSG 361_ SWYVE 366_ TLDDI 371_ FEQWA 376_ HSEDL 381_ QSLLL 386_ RVANA 391_ VSVKG 396_ IYKQM 401_ PGCFN 406_ FLRKK 411_LFFKT
1: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106)
2: Lacks activity is an dominant-negative inhibitor of caspase-9