Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75)
1_MPHLM 6_ ERMVG 11_ SGLLW 16_ LALVS 21_ CILTQ 26_ ASAVQ 31_ RGYGN 36_ PIEAS 41_ SYGLD 46_ LDCGA 51_ PGTPE 56_ AHVCF 61_ DPCQN 66_ YTLLD 71_ EPFRS 76_ TENSA 81_ GSQGC 86_ DKNMS 91_ GWYRF 96_ VGEGG 101_ VRMSE 106_ TCVQV 111_ HRCQT 116_ DAPMW 121_ LNGTH 126_ PALGD 131_ GITNH 136_ TACAH 141_ WSGNC 146_ CFWKT 151_ EVLVK 156_ ACPGG 161_ YHVYR 166_ LEGTP 171_ WCNLR 176_ YCTVP 181_ RDPST 186_ VEDKC 191_ EKACR 196_ PEEEC 201_ LALNS 206_ TWGCF 211_ CRQDL 216_ NSSDV 221_ HSLQP 226_ QLDCG 231_ PREIK 236_ VKVDK 241_ CLLGG 246_ LGLGE 251_ EVIAY 256_ LRDPN 261_ CSSIL 266_ QTEER 271_ NWVSV 276_ TSPVQ 281_ ASACR 286_ NILER 291_ NQTHA 296_ IYKNT 301_ LSLVN 306_ DFIIR 311_ DTILN 316_ INFQC 321_ AYPLD 326_ MKVSL 331_ QAALQ 336_ PIVSS 341_ LNVSV 346_ DGNGE 351_ FIVRM 356_ ALFQD 361_ QNYTN 366_ PYEGD 371_ AVELS 376_ VESVL 381_ YVGAI 386_ LEQGD 391_ TSRFN 396_ LVLRN 401_ CYATP 406_ TEDKA 411_ DLVKY 416_ FIIRN 421_ SCSNQ 426_ RDSTI 431_ HVEEN 436_ GQSSE 441_ SRFSV 446_ QMFMF 451_ AGHYD 456_ LVFLH 461_ CEIHL 466_ CDSLN 471_ EQCQP 476_ SCSRS 481_ QVRSE 486_ VPAID 491_ LARVL 496_ DLGPI 501_ TRRGA 506_ QSPGV 511_ MNGTP 516_ STAGF 521_ LVAWP 526_ MVLLT 531_VLLAW
1: Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response