Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A)
1_MLGTV 6_ KMEGH 11_ ETSDW 16_ NSYYA 21_ DTQEA 26_ YSSVP 31_ VSNMN 36_ SGLGS 41_ MNSMN 46_ TYMTM 51_ NTMTT 56_ SGNMT 61_ PASFN 66_ MSYAN 71_ PGLGA 76_ GLSPG 81_ AVAGM 86_ PGGSA 91_ GAMNS 96_ MTAAG 101_ VTAMG 106_ TALSP 111_ SGMGA 116_ MGAQQ 121_ AASMN 126_ GLGPY 131_ AAAMN 136_ PCMSP 141_ MAYAP 146_ SNLGR 151_ SRAGG 156_ GGDAK 161_ TFKRS 166_ YPHAK 171_ PPYSY 176_ ISLIT 181_ MAIQQ 186_ APSKM 191_ LTLSE 196_ IYQWI 201_ MDLFP 206_ YYRQN 211_ QQRWQ 216_ NSIRH 221_ SLSFN 226_ DCFVK 231_ VARSP 236_ DKPGK 241_ GSYWT 246_ LHPDS 251_ GNMFE 256_ NGCYL 261_ RRQKR 266_ FKCEK 271_ QPGAG 276_ GGGGS 281_ GSGGS 286_ GAKGG 291_ PESRK 296_ DPSGA 301_ SNPSA 306_ DSPLH 311_ RGVHG 316_ KTGQL 321_ EGAPA 326_ PGPAA 331_ SPQTL 336_ DHSGA 341_ TATGG 346_ ASELK 351_ TPASS 356_ TAPPI 361_ SSGPG 366_ ALASV 371_ PASHP 376_ AHGLA 381_ PHESQ 386_ LHLKG 391_ DPHYS 396_ FNHPF 401_ SINNL 406_ MSSSE 411_ QQHKL 416_ DFKAY 421_ EQALQ 426_ YSPYG 431_ STLPA 436_ SLPLG 441_ SASVT 446_ TRSPI 451_ EPSAL 456_ EPAYY 461_ QGVYS 466_RPVLN
1: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis