Protein arginine N-methyltransferase 2 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT2)
1_MATSG 6_ DCPRS 11_ ESQGE 16_ EPAEC 21_ SEAGL 26_ LQEGV 31_ QPEEF 36_ VAIAD 41_ YAATD 46_ ETQLS 51_ FLRGE 56_ KILIL 61_ RQTTA 66_ DWWWG 71_ ERAGC 76_ CGYIP 81_ ANHVG 86_ KHVDE 91_ YDPED 96_ TWQDE 101_ EYFGS 106_ YGTLK 111_ LHLEM 116_ LADQP 121_ RTTKY 126_ HSVIL 131_ QNKES 136_ LTDKV 141_ ILDVG 146_ CGTGI 151_ ISLFC 156_ AHYAR 161_ PRAVY 166_ AVEAS 171_ EMAQH 176_ TGQLV 181_ LQNGF 186_ ADIIT 191_ VYQQK 196_ VEDVV 201_ LPEKV 206_ DVLVS 211_ EWMGT 216_ CLLFE 221_ FMIES 226_ ILYAR 231_ DAWLK 236_ EDGVI 241_ WPTMA 246_ ALHLV 251_ PCSAD 256_ KDYRS 261_ KVLFW 266_ DNAYE 271_ FNLSA 276_ LKSLA 281_ VKEFF 286_ SKPKY 291_ NHILK 296_ PEDCL 301_ SEPCT 306_ ILQLD 311_ MRTVQ 316_ ISDLE 321_ TLRGE 326_ LRFDI 331_ RKAGT 336_ LHGFT 341_ AWFSV 346_ HFQSL 351_ QEGQP 356_ PQVLS 361_ TGPFH 366_ PTTHW 371_ KQTLF 376_ MMDDP 381_ VPVHT 386_ GDVVT 391_ GSVVL 396_ QRNPV 401_ WRRHM 406_ SVALS 411_ WAVTS 416_ RQDPT 421_ SQKVG 426_EKVFP
1: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation