Protein SEC13 homolog (GATOR complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein)
1_MVSVI 6_ NTVDT 11_ SHEDM 16_ IHDAQ 21_ MDYYG 26_ TRLAT 31_ CSSDR 36_ SVKIF 41_ DVRNG 46_ GQILI 51_ ADLRG 56_ HEGPV 61_ WQVAW 66_ AHPMY 71_ GNILA 76_ SCSYD 81_ RKVII 86_ WREEN 91_ GTWEK 96_ SHEHA 101_ GHDSS 106_ VNSVC 111_ WAPHD 116_ YGLIL 121_ ACGSS 126_ DGAIS 131_ LLTYT 136_ GEGQW 141_ EVKKI 146_ NNAHT 151_ IGCNA 156_ VSWAP 161_ AVVPG 166_ SLIDH 171_ PSGQK 176_ PNYIK 181_ RFASG 186_ GCDNL 191_ IKLWK 196_ EEEDG 201_ QWKEE 206_ QKLEA 211_ HSDWV 216_ RDVAW 221_ APSIG 226_ LPTST 231_ IASCS 236_ QDGRV 241_ FIWTC 246_ DDASS 251_ NTWSP 256_ KLLHK 261_ FNDVV 266_ WHVSW 271_ SITAN 276_ ILAVS 281_ GGDNK 286_ VTLWK 291_ ESVDG 296_ QWVCI 301_ SDVNK 306_ GQGSV 311_ SASVT 316_EGQQN
1: Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity)
2: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510)