Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)
1_MWLAA 6_ AAPSL 11_ ARRLL 16_ FLGPP 21_ PPPLL 26_ LLVFS 31_ RSSRR 36_ RLHSL 41_ GLAAM 46_ PEKRP 51_ FERLP 56_ ADVSP 61_ INYSL 66_ CLKPD 71_ LLDFT 76_ FEGKL 81_ EAAAQ 86_ VRQAT 91_ NQIVM 96_ NCADI 101_ DIITA 106_ SYAPE 111_ GDEEI 116_ HATGF 121_ NYQNE 126_ DEKVT 131_ LSFPS 136_ TLQTG 141_ TGTLK 146_ IDFVG 151_ ELNDK 156_ MKGFY 161_ RSKYT 166_ TPSGE 171_ VRYAA 176_ VTQFE 181_ ATDAR 186_ RAFPC 191_ WDEPA 196_ IKATF 201_ DISLV 206_ VPKDR 211_ VALSN 216_ MNVID 221_ RKPYP 226_ DDENL 231_ VEVKF 236_ ARTPV 241_ MSTYL 246_ VAFVV 251_ GEYDF 256_ VETRS 261_ KDGVC 266_ VRVYT 271_ PVGKA 276_ EQGKF 281_ ALEVA 286_ AKTLP 291_ FYKDY 296_ FNVPY 301_ PLPKI 306_ DLIAI 311_ ADFAA 316_ GAMEN 321_ WGLVT 326_ YRETA 331_ LLIDP 336_ KNSCS 341_ SSRQW 346_ VALVV 351_ GHELA 356_ HQWFG 361_ NLVTM 366_ EWWTH 371_ LWLNE 376_ GFASW 381_ IEYLC 386_ VDHCF 391_ PEYDI 396_ WTQFV 401_ SADYT 406_ RAQEL 411_ DALDN 416_ SHPIE 421_ VSVGH 426_ PSEVD 431_ EIFDA 436_ ISYSK 441_ GASVI 446_ RMLHD 451_ YIGDK 456_ DFKKG 461_ MNMYL 466_ TKFQQ 471_ KNAAT 476_ EDLWE 481_ SLENA 486_ SGKPI 491_ AAVMN 496_ TWTKQ 501_ MGFPL 506_ IYVEA 511_ EQVED 516_ DRLLR 521_ LSQKK 526_ FCAGG 531_ SYVGE 536_ DCPQW 541_ MVPIT 546_ ISTSE 551_ DPNQA 556_ KLKIL 561_ MDKPE 566_ MNVVL 571_ KNVKP 576_ DQWVK 581_ LNLGT 586_ VGFYR 591_ TQYSS 596_ AMLES 601_ LLPGI 606_ RDLSL 611_ PPVDR 616_ LGLQN 621_ DLFSL 626_ ARAGI 631_ ISTVE 636_ VLKVM 641_ EAFVN 646_ EPNYT 651_ VWSDL 656_ SCNLG 661_ ILSTL 666_ LSHTD 671_ FYEEI 676_ QEFVK 681_ DVFSP 686_ IGERL 691_ GWDPK 696_ PGEGH 701_ LDALL 706_ RGLVL 711_ GKLGK 716_ AGHKA 721_ TLEEA 726_ RRRFK 731_ DHVEG 736_ KQILS 741_ ADLRS 746_ PVYLT 751_ VLKHG 756_ DGTTL 761_ DIMLK 766_ LHKQA 771_ DMQEE 776_ KNRIE 781_ RVLGA 786_ TLLPD 791_ LIQKV 796_ LTFAL 801_ SEEVR 806_ PQDTV 811_ SVIGG 816_ VAGGS 821_ KHGRK 826_ AAWKF 831_ IKDNW 836_ EELYN 841_ RYQGG 846_ FLISR 851_ LIKLS 856_ VEGFA 861_ VDKMA 866_ GEVKA 871_ FFESH 876_ PAPSA 881_ ERTIQ 886_ QCCEN 891_ ILLNA 896_ AWLKR 901_ DAESI 906_ HQYLL 911_QRKAS
1: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain