FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) (hERV1) (Hepatopoietin)
1_MAAPG 6_ ERGRF 11_ HGGNL 16_ FFLPG 21_ GARSE 26_ MMDDL 31_ ATDAR 36_ GRGAG 41_ RRDAA 46_ ASAST 51_ PAQAP 56_ TSDSP 61_ VAEDA 66_ SRRRP 71_ CRACV 76_ DFKTW 81_ MRTQQ 86_ KRDTK 91_ FREDC 96_ PPDRE 101_ ELGRH 106_ SWAVL 111_ HTLAA 116_ YYPDL 121_ PTPEQ 126_ QQDMA 131_ QFIHL 136_ FSKFY 141_ PCEEC 146_ AEDLR 151_ KRLCR 156_ NHPDT 161_ RTRAC 166_ FTQWL 171_ CHLHN 176_ EVNRK 181_ LGKPD 186_ FDCSK 191_ VDERW 196_RDGWK
1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen
2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration