Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)
1_MAALK 6_ LLSSG 11_ LRLCA 16_ SARGS 21_ GATWY 26_ KGCVC 31_ SFSTS 36_ AHRHT 41_ KFYTD 46_ PVEAV 51_ KDIPD 56_ GATVL 61_ VGGFG 66_ LCGIP 71_ ENLID 76_ ALLKT 81_ GVKGL 86_ TAVSN 91_ NAGVD 96_ NFGLG 101_ LLLRS 106_ KQIKR 111_ MVSSY 116_ VGENA 121_ EFERQ 126_ YLSGE 131_ LEVEL 136_ TPQGT 141_ LAERI 146_ RAGGA 151_ GVPAF 156_ YTPTG 161_ YGTLV 166_ QEGGS 171_ PIKYN 176_ KDGSV 181_ AIASK 186_ PREVR 191_ EFNGQ 196_ HFILE 201_ EAITG 206_ DFALV 211_ KAWKA 216_ DRAGN 221_ VIFRK 226_ SARNF 231_ NLPMC 236_ KAAET 241_ TVVEV 246_ EEIVD 251_ IGAFA 256_ PEDIH 261_ IPQIY 266_ VHRLI 271_ KGEKY 276_ EKRIE 281_ RLSIR 286_ KEGDG 291_ EAKSA 296_ KPGDD 301_ VRERI 306_ IKRAA 311_ LEFED 316_ GMYAN 321_ LGIGI 326_ PLLAS 331_ NFISP 336_ NITVH 341_ LQSEN 346_ GVLGL 351_ GPYPR 356_ QHEAD 361_ ADLIN 366_ AGKET 371_ VTILP 376_ GASFF 381_ SSDES 386_ FAMIR 391_ GGHVD 396_ LTMLG 401_ AMQVS 406_ KYGDL 411_ ANWMI 416_ PGKMV 421_ KGMGG 426_ AMDLV 431_ SSAKT 436_ KVVVT 441_ MEHSA 446_ KGNAH 451_ KIMEK 456_ CTLPL 461_ TGKQC 466_ VNRII 471_ TEKAV 476_ FDVDK 481_ KKGLT 486_ LIELW 491_ EGLTV 496_ DDVQK 501_ STGCD 506_ FAVSP 511_KLMPM
1: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (PubMed:10964512). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)