Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
1_MSEEK 6_ PKEGV 11_ KTEND 16_ HINLK 21_ VAGQD 26_ GSVVQ 31_ FKIKR 36_ HTPLS 41_ KLMKA 46_ YCERQ 51_ GLSMR 56_ QIRFR 61_ FDGQP 66_ INETD 71_ TPAQL 76_ EMEDE 81_ DTIDV 86_ FQQQT 91_ GGVPE 96_SSLAG
1: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744)