Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)
1_MQDAE 6_ NVAVP 11_ EAAEE 16_ RAEPG 21_ QQQPA 26_ AEPPP 31_ AEGLL 36_ RPAGP 41_ GAPEA 46_ AGTEA 51_ SSEEV 56_ GIAEA 61_ GPESE 66_ VRTEP 71_ AAEAE 76_ AASGP 81_ SESPS 86_ PPAAE 91_ ELPGS 96_ HAEPP 101_ VPAQG 106_ EAPGE 111_ QARDE 116_ RSDSR 121_ AQAVS 126_ EDAGG 131_ NEGRA 136_ AEAEP 141_ RALEN 146_ GDADE 151_ PSFSD 156_ PEDFV 161_ DDVSE 166_ EELLG 171_ DVLKD 176_ RPQEA 181_ DGIDS 186_ VIVVD 191_ NVPQV 196_ GPDRL 201_ EKLKN 206_ VIHKI 211_ FSKFG 216_ KITND 221_ FYPEE 226_ DGKTK 231_ GYIFL 236_ EYASP 241_ AHAVD 246_ AVKNA 251_ DGYKL 256_ DKQHT 261_ FRVNL 266_ FTDFD 271_ KYMTI 276_ SDEWD 281_ IPEKQ 286_ PFKDL 291_ GNLRY 296_ WLEEA 301_ ECRDQ 306_ YSVIF 311_ ESGDR 316_ TSIFW 321_ NDVKD 326_ PVSIE 331_ ERARW 336_ TETYV 341_ RWSPK 346_ GTYLA 351_ TFHQR 356_ GIALW 361_ GGEKF 366_ KQIQR 371_ FSHQG 376_ VQLID 381_ FSPCE 386_ RYLVT 391_ FSPLM 396_ DTQDD 401_ PQAII 406_ IWDIL 411_ TGHKK 416_ RGFHC 421_ ESSAH 426_ WPIFK 431_ WSHDG 436_ KFFAR 441_ MTLDT 446_ LSIYE 451_ TPSMG 456_ LLDKK 461_ SLKIS 466_ GIKDF 471_ SWSPG 476_ GNIIA 481_ FWVPE 486_ DKDIP 491_ ARVTL 496_ MQLPT 501_ RQEIR 506_ VRNLF 511_ NVVDC 516_ KLHWQ 521_ KNGDY 526_ LCVKV 531_ DRTPK 536_ GTQGV 541_ VTNFE 546_ IFRMR 551_ EKQVP 556_ VDVVE 561_ MKETI 566_ IAFAW 571_ EPNGS 576_ KFAVL 581_ HGEAP 586_ RISVS 591_ FYHVK 596_ NNGKI 601_ ELIKM 606_ FDKQQ 611_ ANTIF 616_ WSPQG 621_ QFVVL 626_ AGLRS 631_ MNGAL 636_ AFVDT 641_ SDCTV 646_ MNIAE 651_ HYMAS 656_ DVEWD 661_ PTGRY 666_ VVTSV 671_ SWWSH 676_ KVDNA 681_ YWLWT 686_ FQGRL 691_ LQKNN 696_ KDRFC 701_ QLLWR 706_ PRPPT 711_ LLSQE 716_ QIKQI 721_ KKDLK 726_ KYSKI 731_ FEQKD 736_ RLSQS 741_ KASKE 746_ LVERR 751_ RTMME 756_ DFRKY 761_ RKMAQ 766_ ELYME 771_ QKNER 776_ LELRG 781_ GVDTD 786_ ELDSN 791_ VDDWE 796_ EETIE 801_ FFVTE 806_EIIPL
1: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815, PubMed:9388245). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:9388245). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
2: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)