Mitochondrial uncoupling protein 3 (UCP 3) (Solute carrier family 25 member 9)
1_MVGLK 6_ PSDVP 11_ PTMAV 16_ KFLGA 21_ GTAAC 26_ FADLV 31_ TFPLD 36_ TAKVR 41_ LQIQG 46_ ENQAV 51_ QTARL 56_ VQYRG 61_ VLGTI 66_ LTMVR 71_ TEGPC 76_ SPYNG 81_ LVAGL 86_ QRQMS 91_ FASIR 96_ IGLYD 101_ SVKQV 106_ YTPKG 111_ ADNSS 116_ LTTRI 121_ LAGCT 126_ TGAMA 131_ VTCAQ 136_ PTDVV 141_ KVRFQ 146_ ASIHL 151_ GPSRS 156_ DRKYS 161_ GTMDA 166_ YRTIA 171_ REEGV 176_ RGLWK 181_ GTLPN 186_ IMRNA 191_ IVNCA 196_ EVVTY 201_ DILKE 206_ KLLDY 211_ HLLTD 216_ NFPCH 221_ FVSAF 226_ GAGFC 231_ ATVVA 236_ SPVDV 241_ VKTRY 246_ MNSPP 251_ GQYFS 256_ PLDCM 261_ IKMVA 266_ QEGPT 271_ AFYKG 276_ FTPSF 281_ LRLGS 286_ WNVVM 291_ FVTYE 296_ QLKRA 301_ LMKVQ 306_MLRES
1: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:11171965, PubMed:12670931, PubMed:12734183, PubMed:9305858). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458)