Homeobox protein DLX-1
1_MTMTT 6_ MPESL 11_ NSPVS 16_ GKAVF 21_ MEFGP 26_ PNQQM 31_ SPSPM 36_ SHGHY 41_ SMHCL 46_ HSAGH 51_ SQPDG 56_ AYSSA 61_ SSFSR 66_ PLGYP 71_ YVNSV 76_ SSHAS 81_ SPYIS 86_ SVQSY 91_ PGSAS 96_ LAQSR 101_ LEDPG 106_ ADSEK 111_ STVVE 116_ GGEVR 121_ FNGKG 126_ KKIRK 131_ PRTIY 136_ SSLQL 141_ QALNR 146_ RFQQT 151_ QYLAL 156_ PERAE 161_ LAASL 166_ GLTQT 171_ QVKIW 176_ FQNKR 181_ SKFKK 186_ LMKQG 191_ GAALE 196_ GSALA 201_ NGRAL 206_ SAGSP 211_ PVPPG 216_ WNPNS 221_ SSGKG 226_ SGGNA 231_ GSYIP 236_ SYTSW 241_ YPSAH 246_QEAMQ
1: Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity)