Homeobox protein DLX-5
1_MTGVF 6_ DRRVP 11_ SIRSG 16_ DFQAP 21_ FQTSA 26_ AMHHP 31_ SQESP 36_ TLPES 41_ SATDS 46_ DYYSP 51_ TGGAP 56_ HGYCS 61_ PTSAS 66_ YGKAL 71_ NPYQY 76_ QYHGV 81_ NGSAG 86_ SYPAK 91_ AYADY 96_ SYASS 101_ YHQYG 106_ GAYNR 111_ VPSAT 116_ NQPEK 121_ EVTEP 126_ EVRMV 131_ NGKPK 136_ KVRKP 141_ RTIYS 146_ SFQLA 151_ ALQRR 156_ FQKTQ 161_ YLALP 166_ ERAEL 171_ AASLG 176_ LTQTQ 181_ VKIWF 186_ QNKRS 191_ KIKKI 196_ MKNGE 201_ MPPEH 206_ SPSSS 211_ DPMAC 216_ NSPQS 221_ PAVWE 226_ PQGSS 231_ RSLSH 236_ HPHAH 241_ PPTSN 246_ QSPAS 251_ SYLEN 256_ SASWY 261_ TSAAS 266_ SINSH 271_ LPPPG 276_ SLQHP 281_LALAS
1: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding