Histone deacetylase 4 (HD4) (EC 3.5.1.98)
1_MSSQS 6_ HPDGL 11_ SGRDQ 16_ PVELL 21_ NPARV 26_ NHMPS 31_ TVDVA 36_ TALPL 41_ QVAPS 46_ AVPMD 51_ LRLDH 56_ QFSLP 61_ VAEPA 66_ LREQQ 71_ LQQEL 76_ LALKQ 81_ KQQIQ 86_ RQILI 91_ AEFQR 96_ QHEQL 101_ SRQHE 106_ AQLHE 111_ HIKQQ 116_ QEMLA 121_ MKHQQ 126_ ELLEH 131_ QRKLE 136_ RHRQE 141_ QELEK 146_ QHREQ 151_ KLQQL 156_ KNKEK 161_ GKESA 166_ VASTE 171_ VKMKL 176_ QEFVL 181_ NKKKA 186_ LAHRN 191_ LNHCI 196_ SSDPR 201_ YWYGK 206_ TQHSS 211_ LDQSS 216_ PPQSG 221_ VSTSY 226_ NHPVL 231_ GMYDA 236_ KDDFP 241_ LRKTA 246_ SEPNL 251_ KLRSR 256_ LKQKV 261_ AERRS 266_ SPLLR 271_ RKDGP 276_ VVTAL 281_ KKRPL 286_ DVTDS 291_ ACSSA 296_ PGSGP 301_ SSPNN 306_ SSGSV 311_ SAENG 316_ IAPAV 321_ PSIPA 326_ ETSLA 331_ HRLVA 336_ REGSA 341_ APLPL 346_ YTSPS 351_ LPNIT 356_ LGLPA 361_ TGPSA 366_ GTAGQ 371_ QDAER 376_ LTLPA 381_ LQQRL 386_ SLFPG 391_ THLTP 396_ YLSTS 401_ PLERD 406_ GGAAH 411_ SPLLQ 416_ HMVLL 421_ EQPPA 426_ QAPLV 431_ TGLGA 436_ LPLHA 441_ QSLVG 446_ ADRVS 451_ PSIHK 456_ LRQHR 461_ PLGRT 466_ QSAPL 471_ PQNAQ 476_ ALQHL 481_ VIQQQ 486_ HQQFL 491_ EKHKQ 496_ QFQQQ 501_ QLQMN 506_ KIIPK 511_ PSEPA 516_ RQPES 521_ HPEET 526_ EEELR 531_ EHQAL 536_ LDEPY 541_ LDRLP 546_ GQKEA 551_ HAQAG 556_ VQVKQ 561_ EPIES 566_ DEEEA 571_ EPPRE 576_ VEPGQ 581_ RQPSE 586_ QELLF 591_ RQQAL 596_ LLEQQ 601_ RIHQL 606_ RNYQA 611_ SMEAA 616_ GIPVS 621_ FGGHR 626_ PLSRA 631_ QSSPA 636_ SATFP 641_ VSVQE 646_ PPTKP 651_ RFTTG 656_ LVYDT 661_ LMLKH 666_ QCTCG 671_ SSSSH 676_ PEHAG 681_ RIQSI 686_ WSRLQ 691_ ETGLR 696_ GKCEC 701_ IRGRK 706_ ATLEE 711_ LQTVH 716_ SEAHT 721_ LLYGT 726_ NPLNR 731_ QKLDS 736_ KKLLG 741_ SLASV 746_ FVRLP 751_ CGGVG 756_ VDSDT 761_ IWNEV 766_ HSAGA 771_ ARLAV 776_ GCVVE 781_ LVFKV 786_ ATGEL 791_ KNGFA 796_ VVRPP 801_ GHHAE 806_ ESTPM 811_ GFCYF 816_ NSVAV 821_ AAKLL 826_ QQRLS 831_ VSKIL 836_ IVDWD 841_ VHHGN 846_ GTQQA 851_ FYSDP 856_ SVLYM 861_ SLHRY 866_ DDGNF 871_ FPGSG 876_ APDEV 881_ GTGPG 886_ VGFNV 891_ NMAFT 896_ GGLDP 901_ PMGDA 906_ EYLAA 911_ FRTVV 916_ MPIAS 921_ EFAPD 926_ VVLVS 931_ SGFDA 936_ VEGHP 941_ TPLGG 946_ YNLSA 951_ RCFGY 956_ LTKQL 961_ MGLAG 966_ GRIVL 971_ ALEGG 976_ HDLTA 981_ ICDAS 986_ EACVS 991_ ALLGN 996_ ELDPL 1001_ PEKVL 1006_ QQRPN 1011_ ANAVR 1016_ SMEKV 1021_ MEIHS 1026_ KYWRC 1031_ LQRTT 1036_ STAGR 1041_ SLIEA 1046_ QTCEN 1051_ EEAET 1056_ VTAMA 1061_ SLSVG 1066_ VKPAE 1071_ KRPDE 1076_EPMEE
1: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256)