Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))
1_MAVRA 6_ SFENN 11_ CEIGC 16_ FAKLT 21_ NTYCL 26_ VAIGG 31_ SENFY 36_ SVFEG 41_ ELSDT 46_ IPVVH 51_ ASIAG 56_ CRIIG 61_ RMCVG 66_ NRHGL 71_ LVPNN 76_ TTDQE 81_ LQHIR 86_ NSLPD 91_ TVQIR 96_ RVEER 101_ LSALG 106_ NVTTC 111_ NDYVA 116_ LVHPD 121_ LDRET 126_ EEILA 131_ DVLKV 136_ EVFRQ 141_ TVADQ 146_ VLVGS 151_ YCVFS 156_ NQGGL 161_ VHPKT 166_ SIEDQ 171_ DELSS 176_ LLQVP 181_ LVAGT 186_ VNRGS 191_ EVIAA 196_ GMVVN 201_ DWCAF 206_ CGLDT 211_ TSTEL 216_ SVVES 221_ VFKLN 226_ EAQPS 231_ TIATS 236_MRDSL
1: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity)