Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog)
1_MEPHL 6_ LGLLL 11_ GLLLG 16_ GTRVL 21_ AGYPI 26_ WWSLA 31_ LGQQY 36_ TSLGS 41_ QPLLC 46_ GSIPG 51_ LVPKQ 56_ LRFCR 61_ NYIEI 66_ MPSVA 71_ EGVKL 76_ GIQEC 81_ QHQFR 86_ GRRWN 91_ CTTID 96_ DSLAI 101_ FGPVL 106_ DKATR 111_ ESAFV 116_ HAIAS 121_ AGVAF 126_ AVTRS 131_ CAEGT 136_ STICG 141_ CDSHH 146_ KGPPG 151_ EGWKW 156_ GGCSE 161_ DADFG 166_ VLVSR 171_ EFADA 176_ RENRP 181_ DARSA 186_ MNKHN 191_ NEAGR 196_ TTILD 201_ HMHLK 206_ CKCHG 211_ LSGSC 216_ EVKTC 221_ WWAQP 226_ DFRAI 231_ GDFLK 236_ DKYDS 241_ ASEMV 246_ VEKHR 251_ ESRGW 256_ VETLR 261_ AKYSL 266_ FKPPT 271_ ERDLV 276_ YYENS 281_ PNFCE 286_ PNPET 291_ GSFGT 296_ RDRTC 301_ NVTSH 306_ GIDGC 311_ DLLCC 316_ GRGHN 321_ TRTEK 326_ RKEKC 331_ HCIFH 336_ WCCYV 341_ SCQEC 346_IRIYD
1: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406)