Protein Wnt-3a
1_MAPLG 6_ YFLLL 11_ CSLKQ 16_ ALGSY 21_ PIWWS 26_ LAVGP 31_ QYSSL 36_ GSQPI 41_ LCASI 46_ PGLVP 51_ KQLRF 56_ CRNYV 61_ EIMPS 66_ VAEGI 71_ KIGIQ 76_ ECQHQ 81_ FRGRR 86_ WNCTT 91_ VHDSL 96_ AIFGP 101_ VLDKA 106_ TRESA 111_ FVHAI 116_ ASAGV 121_ AFAVT 126_ RSCAE 131_ GTAAI 136_ CGCSS 141_ RHQGS 146_ PGKGW 151_ KWGGC 156_ SEDIE 161_ FGGMV 166_ SREFA 171_ DAREN 176_ RPDAR 181_ SAMNR 186_ HNNEA 191_ GRQAI 196_ ASHMH 201_ LKCKC 206_ HGLSG 211_ SCEVK 216_ TCWWS 221_ QPDFR 226_ AIGDF 231_ LKDKY 236_ DSASE 241_ MVVEK 246_ HRESR 251_ GWVET 256_ LRPRY 261_ TYFKV 266_ PTERD 271_ LVYYE 276_ ASPNF 281_ CEPNP 286_ ETGSF 291_ GTRDR 296_ TCNVS 301_ SHGID 306_ GCDLL 311_ CCGRG 316_ HNARA 321_ ERRRE 326_ KCRCV 331_ FHWCC 336_ YVSCQ 341_ ECTRV 346_YDVHT
1: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720)