Gene name: CLDN15

Uniprot entry:

P56746

Protein names:

Claudin-15

Protein sequence:

1_MSMAV 6_ ETFGF 11_ FMATV 16_ GLLML 21_ GVTLP 26_ NSYWR 31_ VSTVH 36_ GNVIT 41_ TNTIF 46_ ENLWF 51_ SCATD 56_ SLGVY 61_ NCWEF 66_ PSMLA 71_ LSGYI 76_ QACRA 81_ LMITA 86_ ILLGF 91_ LGLLL 96_ GIAGL 101_ RCTNI 106_ GGLEL 111_ SRKAK 116_ LAATA 121_ GALHI 126_ LAGIC 131_ GMVAI 136_ SWYAF 141_ NITRD 146_ FFDPL 151_ YPGTK 156_ YELGP 161_ ALYLG 166_ WSASL 171_ ISILG 176_ GLCLC 181_ SACCC 186_ GSDED 191_ PAASA 196_ RRPYQ 201_ APVSV 206_ MPVAT 211_ SDQEG 216_ DSSFG 221_KYGRN

Protein annotations

Protein functions:

1: Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:12055082, PubMed:13129853, PubMed:31188544, PubMed:35650657, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity)