Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
1_MAQAL 6_ PWLLL 11_ WMGAG 16_ VLPAH 21_ GTQHG 26_ IRLPL 31_ RSGLG 36_ GAPLG 41_ LRLPR 46_ ETDEE 51_ PEEPG 56_ RRGSF 61_ VEMVD 66_ NLRGK 71_ SGQGY 76_ YVEMT 81_ VGSPP 86_ QTLNI 91_ LVDTG 96_ SSNFA 101_ VGAAP 106_ HPFLH 111_ RYYQR 116_ QLSST 121_ YRDLR 126_ KGVYV 131_ PYTQG 136_ KWEGE 141_ LGTDL 146_ VSIPH 151_ GPNVT 156_ VRANI 161_ AAITE 166_ SDKFF 171_ INGSN 176_ WEGIL 181_ GLAYA 186_ EIARP 191_ DDSLE 196_ PFFDS 201_ LVKQT 206_ HVPNL 211_ FSLQL 216_ CGAGF 221_ PLNQS 226_ EVLAS 231_ VGGSM 236_ IIGGI 241_ DHSLY 246_ TGSLW 251_ YTPIR 256_ REWYY 261_ EVIIV 266_ RVEIN 271_ GQDLK 276_ MDCKE 281_ YNYDK 286_ SIVDS 291_ GTTNL 296_ RLPKK 301_ VFEAA 306_ VKSIK 311_ AASST 316_ EKFPD 321_ GFWLG 326_ EQLVC 331_ WQAGT 336_ TPWNI 341_ FPVIS 346_ LYLMG 351_ EVTNQ 356_ SFRIT 361_ ILPQQ 366_ YLRPV 371_ EDVAT 376_ SQDDC 381_ YKFAI 386_ SQSST 391_ GTVMG 396_ AVIME 401_ GFYVV 406_ FDRAR 411_ KRIGF 416_ AVSAC 421_ HVHDE 426_ FRTAA 431_ VEGPF 436_ VTLDM 441_ EDCGY 446_ NIPQT 451_ DESTL 456_ MTIAY 461_ VMAAI 466_ CALFM 471_ LPLCL 476_ MVCQW 481_ RCLRC 486_ LRQQH 491_ DDFAD 496_DISLL
1: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity)