Claudin-18
1_MSTTT 6_ CQVVA 11_ FLLSI 16_ LGLAG 21_ CIAAT 26_ GMDMW 31_ STQDL 36_ YDNPV 41_ TSVFQ 46_ YEGLW 51_ RSCVR 56_ QSSGF 61_ TECRP 66_ YFTIL 71_ GLPAM 76_ LQAVR 81_ ALMIV 86_ GIVLG 91_ AIGLL 96_ VSIFA 101_ LKCIR 106_ IGSME 111_ DSAKA 116_ NMTLT 121_ SGIMF 126_ IVSGL 131_ CAIAG 136_ VSVFA 141_ NMLVT 146_ NFWMS 151_ TANMY 156_ TGMGG 161_ MVQTV 166_ QTRYT 171_ FGAAL 176_ FVGWV 181_ AGGLT 186_ LIGGV 191_ MMCIA 196_ CRGLA 201_ PEETN 206_ YKAVS 211_ YHASG 216_ HSVAY 221_ KPGGF 226_ KASTG 231_ FGSNT 236_ KNKKI 241_ YDGGA 246_ RTEDE 251_ VQSYP 256_SKHDY
1: Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (By similarity). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (By similarity). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (By similarity). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (By similarity). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (By similarity)
2: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection
3: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification