3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)
1_MRKVV 6_ LITGA 11_ SSGIG 16_ LALCK 21_ RLLAE 26_ DDELH 31_ LCLAC 36_ RNMSK 41_ AEAVC 46_ AALLA 51_ SHPTA 56_ EVTIV 61_ QVDVS 66_ NLQSV 71_ FRASK 76_ ELKQR 81_ FQRLD 86_ CIYLN 91_ AGIMP 96_ NPQLN 101_ IKALF 106_ FGLFS 111_ RKVIH 116_ MFSTA 121_ EGLLT 126_ QGDKI 131_ TADGL 136_ QEVFE 141_ TNVFG 146_ HFILI 151_ RELEP 156_ LLCHS 161_ DNPSQ 166_ LIWTS 171_ SRSAR 176_ KSNFS 181_ LEDFQ 186_ HSKGK 191_ EPYSS 196_ SKYAT 201_ DLLSV 206_ ALNRN 211_ FNQQG 216_ LYSNV 221_ ACPGT 226_ ALTNL 231_ TYGIL 236_ PPFIW 241_ TLLMP 246_ AILLL 251_ RFFAN 256_ AFTLT 261_ PYNGT 266_ EALVW 271_ LFHQK 276_ PESLN 281_ PLIKY 286_ LSATT 291_ GFGRN 296_ YIMTQ 301_ KMDLD 306_ EDTAE 311_ KFYQK 316_ LLELE 321_ KHIRV 326_ TIQKT 331_ DNQAR 336_LSGSC
1: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:11165030, PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:19772289, PubMed:20659585). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b-diol (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:11165030, PubMed:12829805, PubMed:20659585)
2: Does not have enzymatic activities toward E1 and DHT