Syntaxin-17
1_MSEDE 6_ EKVKL 11_ RRLEP 16_ AIQKF 21_ IKIVI 26_ PTDLE 31_ RLRKH 36_ QINIE 41_ KYQRC 46_ RIWDK 51_ LHEEH 56_ INAGR 61_ TVQQL 66_ RSNIR 71_ EIEKL 76_ CLKVR 81_ KDDLV 86_ LLKRM 91_ IDPVK 96_ EEASA 101_ ATAEF 106_ LQLHL 111_ ESVEE 116_ LKKQF 121_ NDEET 126_ LLQPP 131_ LTRSM 136_ TVGGA 141_ FHTTE 146_ AEASS 151_ QSLTQ 156_ IYALP 161_ EIPQD 166_ QNAAE 171_ SWETL 176_ EADLI 181_ ELSQL 186_ VTDFS 191_ LLVNS 196_ QQEKI 201_ DSIAD 206_ HVNSA 211_ AVNVE 216_ EGTKN 221_ LGKAA 226_ KYKLA 231_ ALPVA 236_ GALIG 241_ GMVGG 246_ PIGLL 251_ AGFKV 256_ AGIAA 261_ ALGGG 266_ VLGFT 271_ GGKLI 276_ QRKKQ 281_ KMMEK 286_ LTSSC 291_ PDLPS 296_QTDKK
1: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion (PubMed:23217709, PubMed:25686604, PubMed:28306502). STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604, PubMed:28306502, PubMed:28504273). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355)