Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) [Cleaved into: Neuregulin-3 (NRG-3)]
1_MSEGA 6_ AAASP 11_ PGAAS 16_ AAAAS 21_ AEEGT 26_ AAAAA 31_ AAAAG 36_ GGPDG 41_ GGEGA 46_ AEPPR 51_ ELRCS 56_ DCIVW 61_ NRQQT 66_ WLCVV 71_ PLFIG 76_ FIGLG 81_ LSLML 86_ LKWIV 91_ VGSVK 96_ EYVPT 101_ DLVDS 106_ KGMGQ 111_ DPFFL 116_ SKPSS 121_ FPKAM 126_ ETTTT 131_ TTSTT 136_ SPATP 141_ SAGGA 146_ ASSRT 151_ PNRIS 156_ TRLTT 161_ ITRAP 166_ TRFPG 171_ HRVPI 176_ RASPR 181_ STTAR 186_ NTAAP 191_ ATVPS 196_ TTAPF 201_ FSSST 206_ LGSRP 211_ PVPGT 216_ PSTQA 221_ MPSWP 226_ TAAYA 231_ TSSYL 236_ HDSTP 241_ SWTLS 246_ PFQDA 251_ ASSSS 256_ SSSSS 261_ ATTTT 266_ PETST 271_ SPKFH 276_ TTTYS 281_ TERSE 286_ HFKPC 291_ RDKDL 296_ AYCLN 301_ DGECF 306_ VIETL 311_ TGSHK 316_ HCRCK 321_ EGYQG 326_ VRCDQ 331_ FLPKT 336_ DSILS 341_ DPTDH 346_ LGIEF 351_ MESEE 356_ VYQRQ 361_ VLSIS 366_ CIIFG 371_ IVIVG 376_ MFCAA 381_ FYFKS 386_ KKQAK 391_ QIQEQ 396_ LKVPQ 401_ NGKSY 406_ SLKAS 411_ STMAK 416_ SENLV 421_ KSHVQ 426_ LQNYS 431_ KVERH 436_ PVTAL 441_ EKMME 446_ SSFVG 451_ PQSFP 456_ EVPSP 461_ DRGSQ 466_ SVKHH 471_ RSLSS 476_ CCSPG 481_ QRSGM 486_ LHRNA 491_ FRRTP 496_ PSPRS 501_ RLGGI 506_ VGPAY 511_ QQLEE 516_ SRIPD 521_ QDTIP 526_ CQGIE 531_ VRKTI 536_ SHLPI 541_ QLWCV 546_ ERPLD 551_ LKYSS 556_ SGLKT 561_ QRNTS 566_ INMQL 571_ PSRET 576_ NPYFN 581_ SLEQK 586_ DLVGY 591_ SSTRA 596_ SSVPI 601_ IPSVG 606_ LEETC 611_ LQMPG 616_ ISEVK 621_ SIKWC 626_ KNSYS 631_ ADVVN 636_ VSIPV 641_ SDCLI 646_ AEQQE 651_ VKILL 656_ ETVQE 661_ QIRIL 666_ TDARR 671_ SEDYE 676_ LASVE 681_ TEDSA 686_ SENTA 691_ FLPLS 696_ PTAKS 701_ EREAQ 706_ FVLRN 711_EIQRD
1: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes