Histone H2B type F-S (H2B-clustered histone 12 like) (H2B.S histone 1) (Histone H2B.s) (H2B/s)
1_MPEPA 6_ KSAPA 11_ PKKGS 16_ KKAVT 21_ KAQKK 26_ DGRKR 31_ KRSRK 36_ ESYSV 41_ YVYKV 46_ LKQVH 51_ PDTGI 56_ SSKAM 61_ GIMNS 66_ FVNDI 71_ FERIA 76_ GEASR 81_ LPHYN 86_ KRSTI 91_ TSREI 96_ QTAVR 101_ LLLPG 106_ ELAKH 111_ AVSEG 116_ TKAVT 121_KYTSA
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
2: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid