Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
1_MAAGE 6_ TQLYA 11_ KVSNK 16_ LKSRS 21_ SPSLL 26_ EPLLA 31_ MGFPV 36_ HTALK 41_ ALAAT 46_ GRKTA 51_ EEALA 56_ WLHDH 61_ CNDPS 66_ LDDPI 71_ PQEYA 76_ LFLCP 81_ TGPLL 86_ EKLQE 91_ FWRES 96_ KRQCA 101_ KNRAH 106_ EVFPH 111_ VTLCD 116_ FFTCE 121_ DQKVE 126_ CLYEA 131_ LKRAG 136_ DRLLG 141_ SFPTA 146_ VPLAL 151_ HSSIS 156_ YLGFF 161_ VSGSP 166_ ADVIR 171_ EFAMT 176_ FATEA 181_ SLLAG 186_ TSVSR 191_ FWIFS 196_ QVPGH 201_ GPNLR 206_ LSNLT 211_ RASFV 216_ SHYIL 221_ QKYCS 226_ VKPCT 231_ KQLHL 236_ TLAHK 241_ FYPHH 246_ QRTLE 251_ QLARA 256_ IPLGH 261_ SCQWT 266_ AALYS 271_ RDMRF 276_ VHYQT 281_ LRALF 286_ QYKPQ 291_ NVDEL 296_ TLSPG 301_ DYIFV 306_ DPTQQ 311_ DEASE 316_ GWVIG 321_ ISQRT 326_ GCRGF 331_ LPENY 336_ TDRAS 341_ ESDTW 346_ VKHRM 351_ YTFSL 356_ ATDLN 361_ SRKDG 366_ EASSR 371_ CSGEF 376_ LPQTA 381_ RSLSS 386_ LQALQ 391_ ATVAR 396_ KSVLV 401_ VRHGE 406_ RVDQI 411_ FGKAW 416_ LQQCS 421_ TPDGK 426_ YYRPD 431_ LNFPC 436_ SLPRR 441_ SRGIK 446_ DFEND 451_ PPLSS 456_ CGIFQ 461_ SRIAG 466_ DALLD 471_ SGIRI 476_ SSVFA 481_ SPALR 486_ CVQTA 491_ KLILE 496_ ELKLE 501_ KKIKI 506_ RVEPG 511_ IFEWT 516_ KWEAG 521_ KTTPT 526_ LMSLE 531_ ELKEA 536_ NFNID 541_ TDYRP 546_ AFPLS 551_ ALMPA 556_ ESYQE 561_ YMDRC 566_ TASMV 571_ QIVNT 576_ CPQDT 581_ GVILI 586_ VSHGS 591_ TLDSC 596_ TRPLL 601_ GLPPR 606_ ECGDF 611_ AQLVR 616_ KIPSL 621_ GMCFC 626_ EENKE 631_ EGKWE 636_ LVNPP 641_ VKTLT 646_ HGANA 651_ AFNWR 656_NWISG
1: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain