Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
1_MEGDG 6_ GTPWA 11_ LALLR 16_ TFDAG 21_ EFTGW 26_ EKVGS 31_ GGFGQ 36_ VYKVR 41_ HVHWK 46_ TWLAI 51_ KCSPS 56_ LHVDD 61_ RERME 66_ LLEEA 71_ KKMEM 76_ AKFRY 81_ ILPVY 86_ GICRE 91_ PVGLV 96_ MEYME 101_ TGSLE 106_ KLLAS 111_ EPLPW 116_ DLRFR 121_ IIHET 126_ AVGMN 131_ FLHCM 136_ APPLL 141_ HLDLK 146_ PANIL 151_ LDAHY 156_ HVKIS 161_ DFGLA 166_ KCNGL 171_ SHSHD 176_ LSMDG 181_ LFGTI 186_ AYLPP 191_ ERIRE 196_ KSRLF 201_ DTKHD 206_ VYSFA 211_ IVIWG 216_ VLTQK 221_ KPFAD 226_ EKNIL 231_ HIMVK 236_ VVKGH 241_ RPELP 246_ PVCRA 251_ RPRAC 256_ SHLIR 261_ LMQRC 266_ WQGDP 271_ RVRPT 276_ FQGNG 281_ LNGEL 286_ IRQVL 291_ AALLP 296_ VTGRW 301_ RSPGE 306_ GFRLE 311_ SEVII 316_ RVTCP 321_ LSSPQ 326_ EITSE 331_ TEDLC 336_ EKPDD 341_ EVKET 346_ AHDLD 351_ VKSPP 356_ EPRSE 361_ VVPAR 366_ LKRAS 371_ APTFD 376_ NDYSL 381_ SELLS 386_ QLDSG 391_ VSQAV 396_ EGPEE 401_ LSRSS 406_ SESKL 411_ PSSGS 416_ GKRLS 421_ GVSSV 426_ DSAFS 431_ SRGSL 436_ SLSFE 441_ REPST 446_ SDLGT 451_ TDVQK 456_ KKLVD 461_ AIVSG 466_ DTSKL 471_ MKILQ 476_ PQDVD 481_ LALDS 486_ GASLL 491_ HLAVE 496_ AGQEE 501_ CAKWL 506_ LLNNA 511_ NPNLS 516_ NRRGS 521_ TPLHM 526_ AVERR 531_ VRGVV 536_ ELLLA 541_ RKISV 546_ NAKDE 551_ DQWTA 556_ LHFAA 561_ QNGDE 566_ SSTRL 571_ LLEKN 576_ ASVNE 581_ VDFEG 586_ RTPMH 591_ VACQH 596_ GQENI 601_ VRILL 606_ RRGVD 611_ VSLQG 616_ KDAWL 621_ PLHYA 626_ AWQGH 631_ LPIVK 636_ LLAKQ 641_ PGVSV 646_ NAQTL 651_ DGRTP 656_ LHLAA 661_ QRGHY 666_ RVARI 671_ LIDLC 676_ SDVNV 681_ CSLLA 686_ QTPLH 691_ VAAET 696_ GHTST 701_ ARLLL 706_ HRGAG 711_ KEAMT 716_ SDGYT 721_ ALHLA 726_ ARNGH 731_ LATVK 736_ LLVEE 741_ KADVL 746_ ARGPL 751_ NQTAL 756_ HLAAA 761_ HGHSE 766_ VVEEL 771_ VSADV 776_ IDLFD 781_ EQGLS 786_ ALHLA 791_ AQGRH 796_ AQTVE 801_ TLLRH 806_ GAHIN 811_ LQSLK 816_ FQGGH 821_ GPAAT 826_LLRRS
1: Serine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By similarity). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564)