Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)
1_MARRS 6_ RHRLL 11_ LLLLR 16_ YLVVA 21_ LGYHK 26_ AYGFS 31_ APKDQ 36_ QVVTA 41_ VEYQE 46_ AILAC 51_ KTPKK 56_ TVSSR 61_ LEWKK 66_ LGRSV 71_ SFVYY 76_ QQTLQ 81_ GDFKN 86_ RAEMI 91_ DFNIR 96_ IKNVT 101_ RSDAG 106_ KYRCE 111_ VSAPS 116_ EQGQN 121_ LEEDT 126_ VTLEV 131_ LVAPA 136_ VPSCE 141_ VPSSA 146_ LSGTV 151_ VELRC 156_ QDKEG 161_ NPAPE 166_ YTWFK 171_ DGIRL 176_ LENPR 181_ LGSQS 186_ TNSSY 191_ TMNTK 196_ TGTLQ 201_ FNTVS 206_ KLDTG 211_ EYSCE 216_ ARNSV 221_ GYRRC 226_ PGKRM 231_ QVDDL 236_ NISGI 241_ IAAVV 246_ VVALV 251_ ISVCG 256_ LGVCY 261_ AQRKG 266_ YFSKE 271_ TSFQK 276_ SNSSS 281_ KATTM 286_ SENDF 291_KHTKS
1: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:11590146, PubMed:11823489, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:12239159). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:12070135). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity)