Transmembrane protein 33 (Protein DB83) (SHINC-3)
1_MADTT 6_ PNGPQ 11_ GAGAV 16_ QFMMT 21_ NKLDT 26_ AMWLS 31_ RLFTV 36_ YCSAL 41_ FVLPL 46_ LGLHE 51_ AASFY 56_ QRALL 61_ ANALT 66_ SALRL 71_ HQRLP 76_ HFQLS 81_ RAFLA 86_ QALLE 91_ DSCHY 96_ LLYSL 101_ IFVNS 106_ YPVTM 111_ SIFPV 116_ LLFSL 121_ LHAAT 126_ YTKKV 131_ LDARG 136_ SNSLP 141_ LLRSV 146_ LDKLS 151_ ANQQN 156_ ILKFI 161_ ACNEI 166_ FLMPA 171_ TVFML 176_ FSGQG 181_ SLLQP 186_ FIYYR 191_ FLTLR 196_ YSSRR 201_ NPYCR 206_ TLFNE 211_ LRIVV 216_ EHIIM 221_ KPACP 226_ LFVRR 231_ LCLQS 236_ IAFIS 241_RLAPT
1: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377)