Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)
1_MAWLR 6_ LQPLT 11_ SAFLH 16_ FGLVT 21_ FVLFL 26_ NGLRA 31_ EAGGS 36_ GDVPS 41_ TGQNN 46_ ESCSG 51_ SSDCK 56_ EGVIL 61_ PIWYP 66_ ENPSL 71_ GDKIA 76_ RVIVY 81_ FVALI 86_ YMFLG 91_ VSIIA 96_ DRFMA 101_ SIEVI 106_ TSQER 111_ EVTIK 116_ KPNGE 121_ TSTTT 126_ IRVWN 131_ ETVSN 136_ LTLMA 141_ LGSSA 146_ PEILL 151_ SLIEV 156_ CGHGF 161_ IAGDL 166_ GPSTI 171_ VGSAA 176_ FNMFI 181_ IIGIC 186_ VYVIP 191_ DGETR 196_ KIKHL 201_ RVFFI 206_ TAAWS 211_ IFAYI 216_ WLYMI 221_ LAVFS 226_ PGVVQ 231_ VWEGL 236_ LTLFF 241_ FPVCV 246_ LLAWV 251_ ADKRL 256_ LFYKY 261_ MHKKY 266_ RTDKH 271_ RGIII 276_ ETEGD 281_ HPKGI 286_ EMDGK 291_ MMNSH 296_ FLDGN 301_ LVPLE 306_ GKEVD 311_ ESRRE 316_ MIRIL 321_ KDLKQ 326_ KHPEK 331_ DLDQL 336_ VEMAN 341_ YYALS 346_ HQQKS 351_ RAFYR 356_ IQATR 361_ MMTGA 366_ GNILK 371_ KHAAE 376_ QAKKA 381_ SSMSE 386_ VHTDE 391_ PEDFI 396_ SKVFF 401_ DPCSY 406_ QCLEN 411_ CGAVL 416_ LTVVR 421_ KGGDM 426_ SKTMY 431_ VDYKT 436_ EDGSA 441_ NAGAD 446_ YEFTE 451_ GTVVL 456_ KPGET 461_ QKEFS 466_ VGIID 471_ DDIFE 476_ EDEHF 481_ FVRLS 486_ NVRIE 491_ EEQPE 496_ EGMPP 501_ AIFNS 506_ LPLPR 511_ AVLAS 516_ PCVAT 521_ VTILD 526_ DDHAG 531_ IFTFE 536_ CDTIH 541_ VSESI 546_ GVMEV 551_ KVLRT 556_ SGARG 561_ TVIVP 566_ FRTVE 571_ GTAKG 576_ GGEDF 581_ EDTYG 586_ ELEFK 591_ NDETV 596_ KTIRV 601_ KIVDE 606_ EEYER 611_ QENFF 616_ IALGE 621_ PKWME 626_ RGISA 631_ LLLSP 636_ DVTDR 641_ KLTME 646_ EEEAK 651_ RIAEM 656_ GKPVL 661_ GEHPK 666_ LEVII 671_ EESYE 676_ FKTTV 681_ DKLIK 686_ KTNLA 691_ LVVGT 696_ HSWRD 701_ QFMEA 706_ ITVSA 711_ AGDED 716_ EDESG 721_ EERLP 726_ SCFDY 731_ VMHFL 736_ TVFWK 741_ VLFAC 746_ VPPTE 751_ YCHGW 756_ ACFAV 761_ SILII 766_ GMLTA 771_ IIGDL 776_ ASHFG 781_ CTIGL 786_ KDSVT 791_ AVVFV 796_ AFGTS 801_ VPDTF 806_ ASKAA 811_ ALQDV 816_ YADAS 821_ IGNVT 826_ GSNAV 831_ NVFLG 836_ IGLAW 841_ SVAAI 846_ YWALQ 851_ GQEFH 856_ VSAGT 861_ LAFSV 866_ TLFTI 871_ FAFVC 876_ ISVLL 881_ YRRRP 886_ HLGGE 891_ LGGPR 896_ GCKLA 901_ TTWLF 906_ VSLWL 911_ LYILF 916_ ATLEA 921_YCYIK
1: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity)