Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97)
1_MDLGP 6_ LNICE 11_ EMTIL 16_ HGGFL 21_ LAEQL 26_ FHPKA 31_ LAELT 36_ KSDWE 41_ RVGRP 46_ IVEAL 51_ REISS 56_ AAAHS 61_ QPFAW 66_ KKKAL 71_ IIIWA 76_ KVLQP 81_ HPVTP 86_ SDTET 91_ RWQED 96_ LFFSV 101_ GNMIP 106_ TINHT 111_ ILFEL 116_ LKSLE 121_ ASGLF 126_ IQLLM 131_ ALPTT 136_ ICHAE 141_ LERFL 146_ EHVTV 151_ DTSAE 156_ DVAFF 161_ LDVWW 166_ EVMKH 171_ KGHPQ 176_ DPLLS 181_ QFSAM 186_ AHKYL 191_ PALDE 196_ FPHPP 201_ KRLRS 206_ DPDAC 211_ PTMPL 216_ LAMLL 221_ RGLTQ 226_ IQSRI 231_ LGPGR 236_ KCCAL 241_ ANLAD 246_ MLTVF 251_ ALTED 256_ DPQEV 261_ SATVY 266_ LDKLA 271_ TVISV 276_ WNSDT 281_ QNPYH 286_ QQALA 291_ EKVKE 296_ AERDV 301_ SLTSL 306_ AKLPS 311_ ETIFV 316_ GCEFL 321_ HHLLR 326_ EWGEE 331_ LQAVL 336_ RSSQG 341_ TSYDS 346_ YRLCD 351_ SLTSF 356_ SQNAT 361_ LYLNR 366_ TSLSK 371_ EDRQV 376_ VSELA 381_ ECVRD 386_ FLRKT 391_ STVLK 396_ NRALE 401_ DITAS 406_ IAMAV 411_ IQQKM 416_ DRHME 421_ VCYIF 426_ ASEKK 431_ WAFSD 436_ EWVAC 441_ LGSNR 446_ ALFRQ 451_ PDLVL 456_ RLLET 461_ VIDVS 466_ TADRA 471_ IPESQ 476_ IRQVI 481_ HLILE 486_ CYADL 491_ SLPGK 496_ NKVLA 501_ GILRS 506_ WGRKG 511_ LSEKL 516_ LAYVE 521_ GFQED 526_ LNTTF 531_ NQLTQ 536_ SASEQ 541_ GLAKA 546_ VASVA 551_ RLVIV 556_ HPEVT 561_ VKKMC 566_ SLAVV 571_ NLGTH 576_ KFLAQ 581_ ILTAF 586_ PALRF 591_ VEEQG 596_ PNSSA 601_ TFMVS 606_ CLKET 611_ VWMKF 616_ STPKE 621_ EKQFL 626_ ELLNC 631_ LMSPV 636_ KPQGI 641_ PVAAL 646_ LEPDE 651_ VLKEF 656_ VLPFL 661_ RLDVE 666_ EVDLS 671_ LRIFI 676_ QTLEA 681_ NACRE 686_ EYWLQ 691_ TCSPF 696_ PLLFS 701_ LCQLL 706_ DRFSK 711_ YWQLP 716_ KEKRC 721_ LSLDR 726_ KDLAI 731_ HILEL 736_ LCEIV 741_ SANAE 746_ TFSPD 751_ VWIKS 756_ LSWLH 761_ RKLEQ 766_ LDWTV 771_ GLRLK 776_ SFFEG 781_ HFKCE 786_ VPATL 791_ FEICK 796_ LSEDE 801_ WTSQA 806_ HPGYG 811_ AGTGL 816_ LAWME 821_ CCCVS 826_ SGISE 831_ RMLSL 836_ LVVDV 841_ GNPEE 846_ VRLFS 851_ KGFLV 856_ ALVQV 861_ MPWCS 866_ PQEWQ 871_ RLHQL 876_ TRRLL 881_ EKQLL 886_ HVPYS 891_ LEYIQ 896_ FVPLL 901_ NLKPF 906_ AQELQ 911_ LSVLF 916_ LRTFQ 921_ FLCSH 926_ SCRDW 931_ LPLEG 936_ WNHVV 941_ KLLCG 946_ SLTRL 951_ LDSVR 956_ AIQAA 961_ GPWVQ 966_ GPEQD 971_ LTQEA 976_ LFVYT 981_ QVFCH 986_ ALHIM 991_ AMLHP 996_ EVCEP 1001_ LYVLA 1006_ LETLT 1011_ CYETL 1016_ SKTNP 1021_ SVSSL 1026_ LQRAH 1031_ EQRFL 1036_ KSIAE 1041_ GIGPE 1046_ ERRQT 1051_LLQKM
1: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP