Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1)
1_MQAPH 6_ KEHLY 11_ KLLVI 16_ GDLGV 21_ GKTSI 26_ IKRYV 31_ HQNFS 36_ SHYRA 41_ TIGVD 46_ FALKV 51_ LHWDP 56_ ETVVR 61_ LQLWD 66_ IAGQE 71_ RFGNM 76_ TRVYY 81_ REAMG 86_ AFIVF 91_ DVTRP 96_ ATFEA 101_ VAKWK 106_ NDLDS 111_ KLSLP 116_ NGKPV 121_ SVVLL 126_ ANKCD 131_ QGKDV 136_ LMNNG 141_ LKMDQ 146_ FCKEH 151_ GFVGW 156_ FETSA 161_ KENIN 166_ IDEAS 171_ RCLVK 176_ HILAN 181_ ECDLM 186_ ESIEP 191_ DVVKP 196_ HLTST 201_ KVASC 206_SGCAK
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB38 may be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)