Ras-related protein Rab-25 (CATX-8)
1_MGNGT 6_ EEDYN 11_ FVFKV 16_ VLIGE 21_ SGVGK 26_ TNLLS 31_ RFTRN 36_ EFSHD 41_ SRTTI 46_ GVEFS 51_ TRTVM 56_ LGTAA 61_ VKAQI 66_ WDTAG 71_ LERYR 76_ AITSA 81_ YYRGA 86_ VGALL 91_ VFDLT 96_ KHQTY 101_ AVVER 106_ WLKEL 111_ YDHAE 116_ ATIVV 121_ MLVGN 126_ KSDLS 131_ QAREV 136_ PTEEA 141_ RMFAE 146_ NNGLL 151_ FLETS 156_ ALDST 161_ NVELA 166_ FETVL 171_ KEIFA 176_ KVSKQ 181_ RQNSI 186_ RTNAI 191_ TLGSA 196_ QAGQE 201_ PGPGE 206_KRACC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis (PubMed:17925226). Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity)