F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
1_MAAAA 6_ GEEEE 11_ EEEAA 16_ RESAA 21_ RPAAG 26_ PALWR 31_ LPEEL 36_ LLLIC 41_ SYLDM 46_ RALGR 51_ LAQVC 56_ RWLRR 61_ FTSCD 66_ LLWRR 71_ IARAS 76_ LNSGF 81_ TRLGT 86_ DLMTS 91_ VPVKE 96_ RVKVS 101_ QNWRL 106_ GRCRE 111_ GILLK 116_ WRCSQ 121_ MPWMQ 126_ LEDDS 131_ LYISQ 136_ ANFIL 141_ AYQFR 146_ PDGAS 151_ LNRRP 156_ LGVFA 161_ GHDED 166_ VCHFV 171_ LANSH 176_ IVSAG 181_ GDGKI 186_ GIHKI 191_ HSTFT 196_ VKYSA 201_ HEQEV 206_ NCVDC 211_ KGGII 216_ VSGSR 221_ DRTAK 226_ VWPLA 231_ SGRLG 236_ QCLHT 241_ IQTED 246_ RVWSI 251_ AISPL 256_ LSSFV 261_ TGTAC 266_ CGHFS 271_ PLRIW 276_ DLNSG 281_ QLMTH 286_ LGSDF 291_ PPGAG 296_ VLDVM 301_ YESPF 306_ TLLSC 311_ GYDTY 316_ VRYWD 321_ LRTSV 326_ RKCVM 331_ EWEEP 336_ HDSTL 341_ YCLQT 346_ DGNHL 351_ LATGS 356_ SYYGV 361_ VRLWD 366_ RRQRA 371_ CLHAF 376_ PLTST 381_ PLSSP 386_ VYCLR 391_ LTTKH 396_ LYAAL 401_ SYNLH 406_VLDFQ
1: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling